《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (10): 879-882.

• 综述 • 上一篇    下一篇

经颅磁刺激研究及应用进展

张新; 李建军   

  1. 首都医科大学康复医学院,北京市 100068
  • 收稿日期:2006-03-24 出版日期:2006-10-01 发布日期:2006-10-01

Advance in Investigation of Transcranial Magnetic Stimulation (review)

ZHANG Xin, LI Jian-jun   

  1. TheFaculty of Rehabilitation,Capital University of Medical Sciences, Beijing 100068, China
  • Received:2006-03-24 Published:2006-10-01 Online:2006-10-01

摘要: 经颅磁刺激(TMS)是一种非侵入性无痛性的神经系统检测和治疗技术。通过TMS可以检测运动诱发电位(MEP)、中枢运动传导时间(CMCT)、皮质静息期、运动皮质兴奋性等,对中枢神经系统疾病的诊断、评价和监测有重要意义,可提供疾病病理生理机制方面的重要信息。重复TMS具有的调节病变区皮质兴奋性等复杂机制,使其在抑郁症、帕金森病、癫痫、脊髓损伤、卒中等疾病的实验性和应用性治疗研究方面具有的巨大潜在价值,并逐渐被应用于临床神经学、神经康复学和精神心理学领域。

关键词: 经颅磁刺激, 运动诱发电位, 皮质脊髓传导, 治疗, 综述

Abstract: Transcranial magnetic stimulation (TMS) is a non-invasive technique that can activate cortical motor areas and the corticospinal tract without causing the subject discomfort. Since TMS was introduced, numerous applications of this technique have been developed for the evaluation of neurologic diseases. They allow the evaluation of cortex excitability and motor conduction in the central nervous system and have been proved useful in monitoring motor abnormalities and the recovery of motor function. TMS also gives informations on the pathophysiology of the processes underlying the various clinical conditions and contribute to investigate the mechanisms of diseases. In addition, therapeutic use in depression, Parkinson's disease, epilepsy, spinal cord injury and stroke has raised great interest over the past decade. Theapplication of TMS has great potential both as an investigational and as a therapeutical tool in neurology and psychiatry. However, as an infant techniology, there should be further investigation and large randomized trials to be conducted.

Key words: transcranial magnetic stimulation, motor evoked potentials, corticolspinal tract conduction, treatment, review