《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (10): 831-832.

• 专题　儿童康复 • 上一篇    下一篇

A型肉毒毒素治疗痉挛型脑瘫用药剂量分析

刘建军; 纪树荣; 胡莹媛; 李燕春; 吴卫红; 陆华宝; 张雁   

  1. 1.首都医科大学康复医学院,北京市 100068;2.北京博爱医院,北京市 100068
  • 收稿日期:2006-06-19 出版日期:2006-10-01 发布日期:2006-10-01

Optimal Dose of Botulinum Toxic A in Treatment of Spastic Cerebral Palsy

LIU Jian-jun, JI Shu-rong, HU Ying-yuan, et al   

  1. The Faculty of Rehabilitation, Capital University of Medical Sciences, Beijing100068, China
  • Received:2006-06-19 Published:2006-10-01 Online:2006-10-01

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摘要： 目的探讨A型肉毒毒素(BTX-A)阻滞术缓解脑瘫患儿痉挛的最佳用药剂量。方法对61例痉挛型脑瘫患儿(年龄27～144个月)采用BTX-A阻滞术治疗,按BTX-A剂量系数将患儿分为A、B、C、D、E5组,根据Ashworth评分和体重每次用量为30～160IU,平均(69.0±32.4)IU。结果55人次接受BTX-A阻滞术治疗后肌张力有所下降,功能有所提高,有效率为90.16%,疗效持续时间8～32周,平均(17.56±8.30)周。C组(2≤剂量系数<3)的疗效持续时间最长。结论最佳的小腿三头肌的BTX-A用药剂量计算公式为剂量(IU)=(修改的Ashworth评分+2.5)×体重(kg)。

关键词: 脑性瘫痪, 痉挛, A型肉毒毒素, 剂量, 神经阻滞

Abstract: ObjectiveTo investigate the optimal dose of botulinum toxic A (BTX-A) block to relax spasticity in cerebral palsy.Methods61 children (27～144 months old) with spastic cerebral palsy were treated by BTX-A block and divided into A, B, C, D and E groups according to the dose coefficient. The dose of BTX-A block was 30～160 IU (average 69.0±32.4 IU) according to the weight and the score of Modified Ashworth Scale.Results55 BTX-A blocks were successful. The muscles tone turned below and the function were improved. The effective rate was 90.16%. The effective time ranged from 8 weeks to 32 weeks, average 17.56±8.30 weeks. The effective time of the group C (2≤dose-coefficient<3) was the longest in the five groups.ConclusionThe optimal dose of BTX-A block in triceps surae should be counted as follow: dose(IU)=(score of Modified Ashworth Scale+2.5)×weight(kg).

Key words: cerebral palsy, spasticity, botulinum toxic A (BTX-A), dose, nerve block