《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (08): 704-705.

• 综述 • 上一篇    下一篇

脂毒性与胰岛β细胞凋亡研究进展

张奕1; 柳林1; 郭建利2 综述; 刘长山1 审校   

  1. 1.坊医学院附属潍坊市人民医院内分泌科,山东潍坊市 261041;2.安丘市人民医院骨外科,山东安丘市 262100
  • 收稿日期:2005-10-08 出版日期:2006-08-01 发布日期:2006-08-01

Advances in Lipotoxicity and Pancreatic β Cells Apoptosis (review)

ZHANG Yi, LIULin, GUO Jian-li, et al   

  1. The Department of Endocrinology, Weifang People's Hospital Affiliated to Weifang Medical College, Weifang 261041, Shandong, Chin
  • Received:2005-10-08 Published:2006-08-01 Online:2006-08-01

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摘要： β细胞的功能障碍和凋亡是2型糖尿病发生的重要因素。2型糖尿病糖代谢紊乱与脂代谢紊乱并存,脂代谢紊乱促进β细胞凋亡在糖尿病发生中的作用日益引起关注。本文作者综述了脂毒性对胰岛β细胞的损伤,在游离脂肪酸作用下诱导凋亡的因素及其可能的机制。

关键词: 2型糖尿病, 脂代谢紊乱, 细胞凋亡, β细胞

Abstract: Both dysfunction of pancreatic β cells and β cells apoptosis were important factors contributing to type 2 diabetes. Abnormal glucose and lipid metabolism all existed in type 2 diabetes .With the study further progressing, more and more attention were paid to pancreatic β cells apoptosis accelerated by abnormal lipid metabolism. The literature about β cells injury by lipotoxicity, apoptosis induced factors accompanied by free fatty acids, and relevant mechanism was reviewed in this article.

Key words: type 2 diabetes, abnormal lipid metabolism, apoptosis, β cell