《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (08): 661-662.

• 专题 脑损伤及其并发症 • 上一篇    下一篇

亚低温对脑梗死患者血清NSE和SOD的影响

张敏; 何文龙   

  1. 新乡市中心医院神经内科,河南新乡市 453000
  • 收稿日期:2006-03-09 出版日期:2006-08-01 发布日期:2006-08-01

Effect of Mild Hypothermia on NSE and SOD in Serum of Patients with Large-area Cerebral Infarction

ZHANG Min, HE Wen-long   

  1. The Department of Neurology, the Center Hospital of Xinxiang, Xinxiang 453000, Henan, China
  • Received:2006-03-09 Published:2006-08-01 Online:2006-08-01

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被引次数

6

摘要： 目的探讨亚低温对大面积脑梗死患者血清神经元特异性烯醇化酶(NSE)和超氧化物歧化酶(SOD)的影响及临床意义。方法160例大面积脑梗死患者分为治疗组和对照组各80例,对照组采用常规治疗,治疗组在此基础上进行亚低温治疗,两组患者均在治疗前和治疗后第7天、第14天和第30天进行NIHSS神经功能评分,并检测NSE浓度和SOD活力。结果治疗组患者治疗后第14天和第30天的NIHSS评分明显低于对照组(P<0.05),且NSE浓度降,SOD活力升高;两组患者治疗后的呼吸、脉搏、血钾等指标无显著性差异(P>0.05)。结论亚低温治疗可促进大面积脑梗死患者神经功能的恢复,改善预后。

关键词: 亚低温, 大面积脑梗死, 神经元特异性烯醇化酶, 超氧化物歧化酶

Abstract: ObjectiveTo investigate the effect of mild hypothermia on neuron specific enolase (NSE) and superoxide dismutase (SOD) in serum of patients with large-area cerebral infarction.Methods160 cases with large-area cerebral infarction were divided into the treatment group and control group with 80 cases in each group. Patients of the control group were treated with routine therapy. Those of the treatment group were added with mild hypothermia therapy (MHT). The scores of NIHSS were assessed and NSE and SOD in serum were examined before treatment and 7, 14 and 30 days after treatment in two groups.ResultsThe NIHSS score of the treatment group was significantly lower than that of the control group ( P<0.05), and NSE level decreased, SOD vitality increased in the treatment group. Other indexes such as respiratory, pulse, serum kalium and etc of two groups were not different ( P>0.05).ConclusionMHT can improve he nerve function of patients with large-area cerebral infarction recovering and improve prognosis.

Key words: mild hypothermia, large-area cerebral infarction, neuron specific enolase (NSE), superoxide dismutase (SOD)