《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (08): 656-658.

• 专题 脑损伤及其并发症 • 上一篇    下一篇

成年神经发生及其在缺血性脑损伤治疗中的应用前景

姚瑞芹; 李林   

  1. 首都医科大学宣武医院药物研究室,教育部神经变性病学重点实验室 100053
  • 收稿日期:2006-05-17 出版日期:2006-08-01 发布日期:2006-08-01

Adult Neurogenesis and Its Application in Ischemic Brain Injury Therapy (review)

YAO Rui-qin, LI Lin   

  1. The Department of Pharmacology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China
  • Received:2006-05-17 Published:2006-08-01 Online:2006-08-01

PDF (PC)

被引次数

6

摘要： 近年来的研究表明,成年哺乳动物中枢神经系统存在神经干细胞,并且在整个成年期有持续的神经发生。中风能使齿状回颗粒下层和脑室下层的神经发生增加,新产生的神经元能够迁移到损伤区并表达已死亡神经元的标记物。这些研究为脑损伤后的自身修复带来了希望。本文作者主要对成年神经发生和调节以及中风诱导的神经发生和调节进行综述,并进一步探讨中风或其他脑损伤后神经再生的研究方向。

关键词: 神经发生, 脑缺血, 神经干细胞, 综述

Abstract: Recent evidence has shown that neurogenesis occurs throughout adulthood, and neural stem cells reside in the adult central nervous system (CNS) in mammals. Experimental stroke in adult mammals increases neurogenesis from neural stem cells or progenitor cells located in the dentate subgranular zone and the subventricular zone lining the lateral ventricle. New neurons can migrate to the areas of damage regions and express morphological markers characteristic of died neurons. These findings bring hope for self-repair after brain injury. The author of this paper reviewed the adult neurogenesis and its regulation in vivo, and described evidence for stroke-induced neurogenesis and neuronal replacement in the adult, and discussed the future research directions about neurogenesis after stroke and other brain injuries.

Key words: neurogenesis, cerebral ischemia, neural stem cell, review