《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (08): 654-655.

• 专题 脑损伤及其并发症 • 上一篇    下一篇

脑微血管内皮细胞黏附分子表达与缺血性脑损伤研究进展

刘子旺; 王玉来   

  1. 1.北京中医药大学东方医院神经内科,北京市 100078
  • 收稿日期:2006-05-17 出版日期:2006-08-01 发布日期:2006-08-01

Relationship between Expression of Adhesion Molecules by Brain Microvascular Endothelial Cell and Ischemic Brain Damage (review)

LIU Zi-wang, WANG Yu-lai   

  1. The Affiliated Dongfang Hospital, Beijing University of TCM, Beijing 100078, China
  • Received:2006-05-17 Published:2006-08-01 Online:2006-08-01

摘要: 脑微血管内皮表达的细胞黏附分子在生理上参与脑组织正常结构和功能的维持,保证内皮细胞层的连续性、通透血脑屏障等功能,在病理过程中具有介导炎性细胞向正常或炎症组织移动或定位等功能,其中由脑微血管内皮细胞表达的免疫球蛋白超家族和选择素家族两类黏附分子与缺血性脑损伤的发生、发展有密切关系。作者对脑微血管内皮细胞表达的黏附分子与缺血性脑损伤的研究进展进行了综述。

关键词: 脑微血管内皮细胞, 黏附分子, 缺血性脑损伤, 综述

Abstract: The adhesion molecules expressed by brain microvascular endothelial cell maintain the structure and function of brain, ensure the continuity of endothelium cell and penetrate blood-brain barrier in physiology. They also intervene inflammation cells that remove or orientate regular or inflammation organism in pathology. The adhesion molecules of Immunoglobulin supperfamily and Selectin family are expressed by brain microvascular endothelial cell and have affinity with the ischemic brain damage. The advance in research on relationship between the expression of adhesion molecules by brain microvascular endothelial cell and ischemic brain damage is reviewed in this article.

Key words: brain microvascular endothelial cell, adhesion molecules, ischemic brain damage, review