《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (07): 606-607.

• 临床研究 • 上一篇    下一篇

不同类型降压药物对肾内血流动力学长期影响的研究

付治卿1; 周聊生2a; 徐瑞2a; 张华卿2b; 王清2a; 李小鹰1   

  1. 1.解放军总医院老年心内科,北京市 100853;2.山东省千佛山医院a.心内科;b.超声室,山东济南市 250014
  • 收稿日期:2006-01-25 出版日期:2006-07-01 发布日期:2006-07-01

Long-term Effect of Different Antihypertensive Agents on Renal Hemodynamics

FU Zhi-qing, ZHOU Liao-sheng, XU Rui, et al   

  1. Department of Geratologous Cardiology, the General Hospital of PLA, Beijing 100853, China
  • Received:2006-01-25 Published:2006-07-01 Online:2006-07-01

PDF (PC)

摘要： 目的明确不同降压药物对肾内血流动力学的长期影响。方法回顾性分析了接受不同降压药物治疗的高血压病患者52例。根据服用药物的种类分为3组血管紧张素转换酶抑制剂(ACEI)组、钙拮抗剂(CCB)组和β受体阻滞剂(βB)组。采用标准汞柱式血压计以Korotkoff法测量右上臂血压;采用超声多普勒肾血流测定患者服药前后肾内血流的变化。结果ACEI组和CCB组段动脉各项血流参数的改变与血压降低的程度相关;叶间动脉多数指标的变化与血压降低程度之间也相关。但βB组血压降低的程度与多数血流参数的变化无相关性。结论肾内血流动力学的改善与系统血压降低有一定的相关性;同时又与药物自身的作用机制密切相关。

关键词: 高血压病, 肾功能, 降压药, 肾血流

Abstract: ObjectiveTo investigate the long term effect of different antihypertensive agents on renal hemodynamics with ultrasound Doppler.Methods52 essential hypertensive patients were divided into three groups according to the antihypertensive agent they took: angiotensin-converting-enzyme inhibitor (ACEI), calcium channel blocker (CCB) and β-adrenoceptor blocker (βB). The blood pressures of right upper arms were measured with mercury column blood pressure gauge using Korotkoff method. Renal hemodynamics were examined with ultrasound Doppler before and after treatment with agents. ResultsSystolic blood pressure (SBP) and diastolic blood pressure (DBP) of all patients were decreased significantly. An significant correlation was found between the deceases of blood pressure and the betterment of renal homodynamic parameters in ACEI and CCB groups, but not in βB group. ConclusionTo a degree, the betterment of renal hemodynamics is correlation with the reduction of systemic blood pressure and mechanism of action of antihypertensive agents.

Key words: essential hypertension, renal function, antihypertensive agent, renal blood flow