《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (07): 597-598.

• 临床研究 • 上一篇    下一篇

帕罗西汀治疗脑卒中后抑郁疗效观察

罗汝琴1; 胡春华2; 陈仁云3; 王安奇3; 任玉生1   

  1. 1.武汉市武东铁路精神病医院,湖北武汉市 430084;2.武汉市皮肤病防治研究所,湖北武汉市 430030;3.武汉市优抚医院,湖北武汉市 430023
  • 收稿日期:2006-03-01 出版日期:2006-07-01 发布日期:2006-07-01

Effect of Paroxetine on Post-stroke Depression

LUO Ru-qin, HU Chun-hua, CHEN Ren-yun, et al   

  1. Wudong Railway Psychiatric Hospital, Wuhan 430084, Hubei, China
  • Received:2006-03-01 Published:2006-07-01 Online:2006-07-01

PDF (PC)

被引次数

10

摘要： 目的观察帕罗西汀治疗脑卒中后抑郁(PSD)患者的疗效和不良反应。方法随机将82例脑卒中后抑郁患者分为两帕罗西汀组42例和阿米替林组40例,于治疗前及治疗后第2周、第4周、第8周末,对两组患者进行Hamilton抑郁量表(HAMD)和副反应量表(TESS)评定。结果治疗后,两组患者的HAMD评分均较治疗前明显降低(P<0.01),但两组间无显著性差异(P>0.05),帕罗西汀组的不良反应明显较阿米替林组少且轻(P<0.01)。结论帕罗西汀治疗脑卒中后抑郁安全、有效。

关键词: 帕罗西汀, 阿米替林, 脑卒中后抑郁, 治疗

Abstract: ObjectiveTo observe the efficacy and side effects of paroxetine and amitriptyline in the treatment of post-stroke depression (PSD).Methods82 PSD patients were randomly divided into the paroxetine group (n=42) and amitriptyline group (n=40). Before the treatment and at the ends of 2nd, 4th and 8th week after the treatment, all patients in two groups were assessed with Hamilton Depression Scale (HAMD) and TESS.ResultsAfter treatment, HAMD scores of patients of two groups were decreased significantly (P<0.01), but no difference was found between two groups. The side effects of the paroxetine group were obviously fewer and milder than that of amitriptyline group (P<0.01).ConclusionParoxetine is an effective and safe drug in the treatment of PSD.

Key words: paroxetine, amitriptyline, post-stroke depression, treatment