《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (07): 553-555.

• 专题 脊髓损伤康复 •    下一篇

Schwann细胞移植在脊髓损伤治疗中的应用进展

夏雷; 万虹; 王忠诚   

  1. 首都医科大学,北京市神经外科研究所 北京市 100050
  • 收稿日期:2006-04-12 出版日期:2006-07-01 发布日期:2006-07-01

Advance in Treatment of Spinal Cord Injuries with Schwann Cells Transplantion(review)

XIA Lei, WAN Hong, WANG Zhong-cheng   

  1. Beijing Neurosurgical Institute, Beijing 100050, China
  • Received:2006-04-12 Published:2006-07-01 Online:2006-07-01

PDF (PC)

被引次数

13

摘要： Schwann细胞具有很强的神经保护和髓鞘化的能力,是脊髓损伤治疗研究中运用最早和最多的细胞之一。目前Schwann细胞常常作为联合治疗的平台,将各种干预手段整合起来。本文主要讨论Schwann细胞在联合治疗脊髓损伤中所遇到的问题,各种有关Schwann细胞的联合治疗的效果,Schwann细胞共移植对神经干细胞的积极影响,Schwann细胞移植后的存活、迁移情况以及内源性Schwann细胞在脊髓损伤修复中的作用。

关键词: 脊髓损伤, 神经再生, Schwann细胞, 综述

Abstract: Schwann cells (SCs) have potently neuroprotective and myelinization abilities. They are one of the earliest and the most frequently used cells that are applied to therapeutic studies in spinal cord injury. At present, SCs are usually used as a platform for therapeutic alliance to integrate various interventions. This review will mainly discuss the issues met in therapeutic alliances with SCs for spinal cord injuries, results of various therapeutic alliances with SCs, positive effects of co-transplantation with SCs on neural stem cells, survival, migration of SCs after transplantation and roles of endogenetic SCs in repairing spinal cord injury.

Key words: spinal cord injury, neural regeneration, Schwann cells, review