《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (12): 1176-1178.

• 临床研究 • 上一篇    下一篇

血清脂联素水平与老年人脂肪肝的相关性

吴晓琰; 陈雯洁; 陆怡; 施小梅; 俞茂华   

  1. 复旦大学附属华山医院老年病科,上海市 200040
  • 收稿日期:2007-07-03 出版日期:2007-12-01 发布日期:2007-12-01

Relationship between Serum Content of Adiponectin and Hepatic Steatosis in the Elderly

WU Xiao-yan, CHEN Wen-jie, LU Yi, et al   

  1. The Department of Geriatrics, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, Chin
  • Received:2007-07-03 Published:2007-12-01 Online:2007-12-01

摘要: 目的探讨老年人血清脂联素水平的变化,以及老年人脂肪肝与血清脂联素水平和代谢综合征的相关性。方法根据B超检查结果,将264例老年人分为脂肪肝组87例和对照组177例,测定两组老年人的身高、体重、腰围、血脂、血糖、胰岛素和血清脂联素水平,分析上述变量与脂肪肝的相关性,并应用Logistic回归分析评估血清脂联素水平与代谢综合征对老年人脂肪肝的预测性。结果脂肪肝组的脂联素水平明显低于对照组(P<0.01),代谢综合征患病率显著高于对照组(P<0.001),且脂肪肝组的体质量指数、腰围、空腹血糖、餐后2h血糖、胰岛素抵抗指数、总胆固醇、三酰甘油和低密度脂蛋白增高,高密度脂蛋白降低。Lo-gistic回归分析显示,高水平脂联素对脂肪肝有预防作用,而代谢综合征则增加患脂肪肝的危险。结论血清脂联素水平和代谢综合征是预测脂肪肝的有效参数。

关键词: 脂联素, 肥胖, 代谢综合征, 脂肪肝

Abstract: Objective To investigate the change of the serum content of adiponectin in the elderly, and the relationship between hepatic steatosis and the serum content of adiponectin and metabolic syndrome.Methods 264 elderlies were divided into the hepatic steatosis group (87 cases) and control group (177 cases) after B type ultrasonograph examination. The height, weight, waist circumference and levels of serum lipid, glucose, insulin and adiponectin of all cases in the two groups were measured. The relationship between above variables and hepatic steatosis was analyzed. The multiple logistic regression analysis was used to test the efficacy of adiponectin and metabolic syndrome for predicting the probability of having hepatic steatosis in the elderly.Results For the hepatic steatosis group, the serum content of adiponectin was significantly lower than that of the control group ( P<0.01), the frequency of metabolic syndrome was significantly higher than that of the control group ( P<0.01), and the body mass index, waist circumference, blood glucose (fasting blood glucose and postprandial blood glucose), homeostasis model assessment-insulin resistance index, total cholesterol, triglyceride and low density lipoprotein cholesterol increased and high density lipoprotein cholesterol decreased. Logistic regression analysis showed that serum content of adiponectin and metabolic syndrome were associated with the probability of hepatic steatosis.Conclusion The serum content of adiponectin and metabolic syndrome are useful indices for the prediction of hepatic steatosis.

Key words: adiponectin, obesity, metabolic syndrome, hepatic steatosis