《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (12): 1144-1146.

• 综述 • 上一篇    下一篇

髓核组织工程学研究进展

马舟涌; 李放; 常玉立   

  1. 北京军区总医院全军骨科研究所,北京市 100700
  • 收稿日期:2007-07-05 出版日期:2007-12-01 发布日期:2007-12-01

Advance in Research of Nucleus Pulposus Tissue Engineering (review)

MA Zhou-yong, LI Fang, CHANG Yu-li   

  1. The Department of Orthopedic, Beijing Army General Hospital, Beijing 100700, China
  • Received:2007-07-05 Published:2007-12-01 Online:2007-12-01

摘要: 椎间盘退化是临床上一个重大的问题,椎间盘退化起自于椎间盘细胞以及髓核细胞外基质的变化。近年来,随着对椎间盘退变的分子学基础研究的进展,人们提出用生物对策来修复和恢复退变的椎间盘,其中一种很有希望的方法是应用组织工程的方法修复退变的椎间盘,恢复椎间盘组织的功能。作者就种子细胞、细胞支架和生长因子方面髓核组织工程学的研究进展进行综述。

关键词: 髓核细胞, 组织工程, 干细胞, 生长因子, 支架, 综述

Abstract: Disc degeneration is a substantial clinical problem. Disc degeneration begins with a loss of disc cells and alterations in the extracellular matrix of the nucleus pulposus (NP) cells. Recently, as the molecular basis of disc degeneration becomes increasingly understood, various biologic strategies to repair or regenerate the degenerative disc have been suggested. One promising approach for this problem involves the use of tissue engineering to regenerate the degenerative disc for achieving functional tissue repair. The authors reviewed the main progress of the NP tissue engineering from cells, scaffolds, growth factor.

Key words: nucleus pulposus, tissue engineering, stem cells, growth factor, scaffolds, review