《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (12): 1103-1105.

• 专题　脑瘫康复 • 上一篇    下一篇

人神经干细胞移植治疗重度视觉障碍脑瘫患儿的临床观察

栾佐1; 屈素清1; 刘卫鹏1; 胡晓红1; 尹国才1; 金真2; 龚小军1   

  1. 1.海军总医院儿科,北京市 100037;2.解放军306医院,北京市 100101
  • 收稿日期:2007-02-15 出版日期:2007-12-01 发布日期:2007-12-01

Treatment of Heteroptics after Cerebral Palsy with Transplantation of Human Neural Stem Cells into Cerebral Ventricle in Infants: 7 Case Report

LUAN Zuo, QUSu-qing, LIU Wei-peng, et al   

  1. The Department of Pediatrics, the General Hospital of PLA Navy, Beijing 100037, China
  • Received:2007-02-15 Published:2007-12-01 Online:2007-12-01

PDF (PC)

被引次数

36

摘要： 目的观察人神经干细胞(NSCs)移植治疗脑性瘫痪(CP)合并重度视觉障碍患儿的临床疗效。方法取孕11周正常发育人胚胎前脑细胞,经体外培养扩增为人神经干细胞球,并经前囟穿刺注入7例严重视觉障碍CP患儿的脑室。结果移植后,4例患儿在很短时间即出现视觉功能改善,伴有闪光视觉诱发电位、功能核磁的改变。结论人NSCs移植对部分重度视觉障碍脑瘫患儿有治疗作用。

关键词: 神经干细胞, 移植, 视觉障碍, 脑性瘫痪

Abstract: Objective To investigate the clinical effect of human neural stem cells transplantation on severe visual disability infants after cerebral palsy. Methods Cells obtained from the forebrain of an 11-week-old abortive fetus were cultured and expanded for 15 days, then injected into cerebral ventricle of 7 patients. Results Their vision of 4 patients improved, as well as changes of flash visual evoked potential and functional magnetic resonance imaging in a few days after transplantation. Conclusion Neural stem cells transplantation may benefit in some CP children with severe visual disability.

Key words: neural stem cells, transplantation, visual disability, cerebral palsy