《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (11): 1019-102.

• 专题 脊髓损伤康复 • 上一篇    下一篇

术前应用氟比洛芬酯对脊髓损伤患者术后镇痛的效果

王强1,2a; 王增春1,2a; 刘海泉1,2a; 洪毅1,2a   

  1. 1.首都医科大学康复医学院,北京市 100068;2.中国康复研究中心北京博爱医院a.麻醉科;b.脊柱脊髓外科,北京市 100068
  • 收稿日期:2007-01-22 出版日期:2007-11-01 发布日期:2007-11-01

Postoperative Analgesic Effects of Flurbiprofen Axetil Applied Preoperatively on Patients with Spinal Cord Injury

WANG Qiang,WANG Zeng-chun, LIU Hai-quan, et al   

  1. Department of Anesthesiology, Capital Medical University School of Rehabilitation Medicine, Beijing Charity Hospital, China Rehabilitation Research Centre, Beijing 100068, China
  • Received:2007-01-22 Published:2007-11-01 Online:2007-11-01

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摘要： 目的观察术前使用氟比洛芬酯注射液对脊髓损伤患者手术后镇痛的效果。方法46例全麻下接受脊柱手术的脊髓损伤患者随机分为氟比洛芬酯注射液组(F组)和对照组(C组),每组23例。切皮前,F组静脉注入氟比洛芬酯注射液1mg/kg;C组注入生理盐水1ml/kg。观察两组患者术后2h、4h、8h、24h和48h的疼痛视觉模拟评分(VAS)及术后48h内不良反应的发生情况。结果F组术后2h、4h、8h和24h的VAS评分低于C组(P<0.05);但术后48h与C组的VAS评分差异无显著性意义(P>0.05);两组的术后48h内不良反应的发生率差异无显著性意义(P>0.05)。结论术前使用氟比洛芬酯注射液能有效减少脊髓损伤患者在脊柱手术后的疼痛,并且不增加不良反应的发生率。

关键词: 氟比洛芬酯, 超前镇痛, 视觉模拟评分, 脊髓损伤, 不良反应

Abstract: Objective To observe the post-operative analgesic effect of flurbiprofen Axetil applied preoperatively on patients with spinal cord injury(SCI).Methods46 SCI patients undergoing spine surgery under general anesthesia were randomly divided into the flurbiprofen axetil group(group F)and control group(group C)with 23 cases in each group.Before cutting skin,flurbiprofen axetil(1 mg/kg)was injected intravenously in the group F,and normal saline(1 ml/kg)was infected intravenously in the group C.The scores of Visual Analogue Scale(VAS)for pain at postoperative 2,4,8,24,and 48 hours,and the incidence of side effects within 48 hours after operation were recorded.ResultsVAS scores at the time of 2,4,8,and 24 h after operation in the group F were significantly lower than that in the group C(P<0.05).But VAS scores of two groups at 48 h were not significantly different(P>0.05).The incidences of side effects of two groups were also not significantly different(P>0.05).ConclusionFlurbiprofen axetil applied preoperatively can release pain of SCI patients after spine surgery,and does not increase the incidence of side effects.

Key words: flurbiprofen axetil, preemptive analgesia, visual analogue scale(VAS), spinal cord injury, side effect