《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (11): 1008-1010.

• 专题 脊髓损伤康复 • 上一篇    下一篇

Nogo及其受体在脊髓损伤修复中的作用机制

王永堂1; 鲁秀敏2; 曾琳1; 高洁1; 伍亚民1   

  1. 1.第三军医大学大坪医院野战外科研究所 创伤、烧伤与复合伤国家重点实验室,重庆市 400042;2.重庆工学院生物工程学院,重庆市 400050
  • 收稿日期:2007-04-23 出版日期:2007-11-01 发布日期:2007-11-01

Mechanism of Nogo and Its Receptors during Repairing of Spinal Cord Injury (review)

WANG Yong-tang, LU Xiu-min, ZENG Lin, et al   

  1. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, the Third Military Medical University, Chongqing 400042, China
  • Received:2007-04-23 Published:2007-11-01 Online:2007-11-01

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被引次数

34

摘要： 成体哺乳动物中枢神经系统(CNS)髓磷脂可影响神经的可塑性并抑制神经纤维的再生。Nogo-A被认为是中枢神经系统中抑制轴突生长最关键的一种髓磷脂抑制分子。在脊髓损伤(SCI)动物模型中,抑制Nogo-A的活性可明显促进轴突再生及功能改善。Nogo-A及其信号转导机制的研究日益成为SCI修复过程中的研究热点;Nogo-A及其信号转导分子特别是Nogo-66受体(NgR)、p75神经营养素受体(p75NTR)和LINGO-1成为损伤后促进轴突再生、抑制生长锥塌陷的主要治疗靶点。抑制Nogo-A及其受体NgR/p75NTR/LINGO-1可能有助于SCI的修复,促进患者功能的恢复。

关键词: Nogo-A, Nogo受体复合体, 轴突再生, 脊髓损伤, 综述

Abstract: Myelin of the adult mammalian central nervous system(CNS)has been attributed to affect nerve structural plasticity and suppress regeneration of nerve fibers.Nogo-A is possibly the best characterized of a variety of neurite growth inhibitors in CNS myelin.Neutralizing its activity results in improved axon regrowth and functional recovery in experimental spinal cord injury(SCI)models of animals.Nogo-A and its receptors,especially Nogo-66 receptor(NgR),p75 neurotrophin receptor(p75NTR),and LINGO-1 increasingly become the hot spot in the study of SCI repair,and have become the major targets for therapeutic intervention to promote axon regeneration after SCI.Inhibition of Nogo-A and its receptors NgR/p75NTR/LINGO-1 may be promote the regeneration of axon and maximize functional recovery after SCI.

Key words: Nogo-A, Nogo receptor complex, axon regeneration, spinal cord injury, review