《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (07): 661-662.

• 临床研究 • 上一篇    下一篇

经皮自体骨髓干细胞移植治疗骨不连的临床研究

袁进国1; 于明克1; 周志玲2; 朱振安3   

  1. 1.解放军251医院,河北张家口市 075000;2.河北北方学院附属第二医院,河北张家口市 075000;3.上海第二医科大学附属第九医院,上海市 200011
  • 收稿日期:2006-09-22 出版日期:2007-07-01 发布日期:2007-07-01

Effect of Percutaneous Autogenous Bone Marrow Stem Cell Transplant on Bone Nonunion

YUAN Jin-Guo, YUMing-ke, ZHOU Zhi-ling, et al   

  1. The251st Hospital of PLA, Zhangjiakou 075000, Hebei, China
  • Received:2006-09-22 Published:2007-07-01 Online:2007-07-01

PDF (PC)

被引次数

23

摘要： 目的探讨经皮自体骨髓干细胞移植治疗骨不连的疗效。方法将140例骨不连患者分为自体骨移植组(A组)70例及自体骨髓干细胞移植组(B组)70例,经手术治疗,并行简单有效内外固定。结果A组2个月42例(60%)骨折端周围有少量新生骨痂,5个月46例有大量骨痂形成;B组2个月60例骨折端周围有大量新生骨痂,5个月45例有连续骨痂形成。A组平均愈合时间(8.4±1.8)个月,B组平均愈合时间(6.5±2.0)个月,两组间有显著性差异(P<0.05)。治疗期间无明显不良反应。结论经皮自体骨髓干细胞移植较传统植骨治疗骨不连有明显优势。

关键词: 骨髓干细胞, 自体移植, 骨不连, 骨折

Abstract: Objective To investigate the clinical effect of percutaneous autogenous bone marrow stem cell transplant on bone nonunion. Methods 140 patient with bones nonunion were divided into the autogenous bone transplants (A) group and the autogenous bone marrow stem cell transplant (B) group, with 70 cases in each group. They were assessed 2 and 5 months after operation. Results A few calluses could be observed at the end of fracture in 42 cases in group A 2 months after operation, and massive callus formation could be observed in 46 cases 5 months after operation. However, massive callus formation could be observed in 60 cases in group B 2 months after operation, and continual callus formation could be observed in 45 cases 5 months after operation. The mean healing time was (8.4±1.8) months in group A, and (6.5±2.0) months in group B (P<0.05). No side-effects have been observed during the treatment. Conclusion The percutaneous autogenous bone marrow stem cell transplant is more effective on bone nonunion compared with the traditional treatment.

Key words: bone marrow stem cell, autotransplantation, bone nonunion, fracture