《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (07): 637-639.

• 综述 • 上一篇    下一篇

帕金森病研究进展

陈茹   

  1. 同济大学生命科学与技术学院,上海市 200092
  • 收稿日期:2006-11-24 出版日期:2007-07-01 发布日期:2007-07-01

Advance in Parkinson's Disease(review)

CHEN Ru   

  1. Bioscience and Technology School, Tongji University, Shanghai 200092,China
  • Received:2006-11-24 Published:2007-07-01 Online:2007-07-01

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摘要： 帕金森病(PD)是人类常见的神经退行性疾病之一,其病理特征主要是黑质多巴胺能神经元选择性变性死亡。PD可能是多种因素共同作用的结果。所有对PD的治疗都是控制症状,暂不能根治。多巴胺、蛋白质二硫键异构酶、Parkin基因、PINK1基因和α-突触核蛋白等均与PD有关。细胞凋亡可能在多巴胺能神经元变性死亡的过程中发挥了作用。线粒体功能障碍可能是PD的发病机制之一。PD患者的辅酶Q10水平低于正常人,补充辅酶Q10有利于PD的辅助治疗。

关键词: 帕金森病, 诊断, 治疗, 基因, 线粒体, 辅酶Q10, 综述

Abstract: Parkinson's disease (PD) is one of the prevalent neurodegenerative diseases in human being, which is characterized by the selective degeneration and death of dopaminergic neurons in the substantia negra. The etiology of PD is not illuminated yet. Currently this disease is thought to be the result of the co-operation of multiple factors. So far, PD can't be cured, and all the treatments are to control its symptoms. DA, PDI, Parkin gene, PINK1 gene and α-synuclein are all related to PD. Apoptosis may play a role in the degeneration and death of dopaminergic neurons. Disfunction of mitochondria appears to play a role in the pathogenesis of PD. The levels of CoQ10 from PD patients have been reported to be lower than that from normal people, and the supplement of CoQ10 favors the assistant treatment of PD.

Key words: Parkinson's disease, diagnosis, treatment, gene, mitochondria, CoQ10, review