《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (05): 454-455.

• 临床研究 • 上一篇    下一篇

神经干细胞移植治疗外伤性颅内血肿后遗症20例临床疗效分析

程洪斌1,2; 胡韶山1; 郑永日1; 李敏2; 安沂华2,3   

  1. 1.哈尔滨医科大学第二临床医学院神经外科,黑龙江哈尔滨市 150086;2.武警总医院神经干细胞移植科,北京市 100039;3.首都医科大学附属北京天坛医院,北京市 100050
  • 收稿日期:2006-10-10 出版日期:2007-05-01 发布日期:2007-05-01

Effect of Neural Stem Cells Transplantation on Sequela after Traumatic Intracranial Hematoma

CHENG Hong-bin, HU Shao-shan,ZHENG Yong-ri, et al   

  1. The Second Clinical College, Harbin Medical University, Harbin 150086, Heilongjiang, China
  • Received:2006-10-10 Published:2007-05-01 Online:2007-05-01

PDF (PC)

被引次数

23

摘要： 目的探讨应用神经干细胞移植治疗外伤性颅内血肿后遗症的临床疗效。方法对20例外伤性颅内血肿后遗症患者行腰椎穿刺蛛网膜下腔注入神经干细胞,并于第1次术前和第4次术后半年进行功能独立性评定(FIM)。结果患者自我料理、括约肌控制、活动和转移、运动、交流、社会认知都有明显改善(P<0.01)。结论神经干细胞移植可以改善外伤性颅内血肿患者损伤的症状和体征,提高患者生活质量。

关键词: 神经干细胞, 创伤性脑损伤, 功能独立性评定, 脑出血

Abstract: Objective To investigate the curative effect of neural stem cells (NSCs) transplantation on sequela after traumatic intracranial hematoma. Methods 20 patients with sequela after traumatic intracranial hematoma were treated with NSCs transplantation. Cells were engrafted into subarachnoid cavity via lumbar puncture. They were assessed with Functional Independence Measure (FIM) before and half a year after the transplantation. Results The FIM scores were significantly increased after the transplantation (P<0.01).Conclusion NSCs transplantation could promote functional recovery and improve the living quality of patients with sequela after traumatic intracranial hematoma in the aspects of self-care, sphincter control, mobility, locomotion, communication and social adjustment/cooperation.

Key words: neural stem cell, trauma brain injury, Functional Independence Measure, brain hemorrhage