《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (05): 444-445.

• 基础研究 • 上一篇    下一篇

郁金抗四氯化碳致小鼠急性肝损伤的作用

兰凤英1,2; 何静春1; 赵颖3; 赵丽娟1   

  1. 1.吉林大学基础医学院病理生理学教研室,吉林长春市 130021;2.长春医学高等专科学校,吉林长春市 130031;3.通化县人民医院,吉林通化县 134100
  • 收稿日期:2006-12-20 出版日期:2007-05-01 发布日期:2007-05-01

Protective Effect of Curcumae on Acute Hepatic Injuried Mice Induced with Carbon Tetrachloride

LAN Feng-ying, HE Jing-chun,ZHAO Ying,et al   

  1. Department of Pathophysiology School of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin, China
  • Received:2006-12-20 Published:2007-05-01 Online:2007-05-01

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摘要： 目的观察郁金抗四氯化碳所致小鼠急性肝损伤的作用。方法利用四氯化碳复制小鼠急性肝损伤病理模型,以肝指数、血清丙氨酸氨基转移酶(ALT)和天门冬酸氨基转移酶(AST),肝组织丙二醛(MDA)、超氧化物歧化酶(SOD),肝组织HE染色为观测指标,观察不同剂量郁金(2.5g/kg、5g/kg、10g/kg)对急性肝损伤的治疗作用。结果与模型组相比,郁金治疗组肝指数及血清ALT、AST降低(P<0.05);肝组织匀浆中MDA含量下降(P<0.05)、SOD活性增高(P<0.05);HE染色显示:郁金治疗组肝组织受损(肝细胞水肿、气球样变,肝小叶中点状坏死,炎细胞浸润等)程度明显减轻。结论郁金对四氯化碳所致小鼠急性肝损伤具有一定的防治作用。

关键词: 郁金, 四氯化碳, 急性肝损伤, 小鼠

Abstract: Objective To explore the effect of Curcumae on acute hepatic injuried mice.Methods The model mice of acute hepatic injury were established with intraperitoneal injecting 0.2% carbon tetrachloride (CCl4) 0.2 ml/10mg. 48 mice were randomized into 6 groups: model group, control group, Ganlixin group (25 mg/kg) and three treating groups of Curcumae which were administrated by gavage at the doses of 2.5 g/kg, 5 g/kg, 10 g/kg once everyday.7 d later, all mice were put to death. The liver index, the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) in serum, the activities of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in hepatic tissue were observed. Pathological change was observed under HE staining. Results Compared with the model group, Curcumae could decrease the liver index and the activities of ALT and AST in serum, MDA in hepatic tissue significantly (P<0.05), and increase the activities of SOD (P<0.05). The pathological changes were less in three treating groups than that of the models. Conclusion Curcumae can protect the liver from acute hepatic injuried induced with CCl4 in mice.

Key words: Curcumae, carbon tetrachloride, acute hepatic injury, mice