《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (05): 404-406.

• 专题　缺血性脑卒中 • 上一篇    下一篇

强迫性上肢训练对缺血性脑卒中大鼠神经传导束的影响

赵春禹1,2; 张通1,2; 钮竹1,2; 裴志胜1,2; 潘立东1,2   

  1. 1.首都医科大学康复医学院,北京市 100068;2.中国康复研究中心北京博爱医院神经康复科,北京市 100068
  • 收稿日期:2007-02-06 出版日期:2007-05-01 发布日期:2007-05-01

Effects of Constraint-induced Movement Training on Neurological Medullary Sheath in Rats after Middle Cerebral Artery Occlusion

ZHAO Chun-yu, ZHANG Tong, NIU Zhu, et al   

  1. School of Rehabilitation, Capital Medical University, Beijing 100068,China
  • Received:2007-02-06 Published:2007-05-01 Online:2007-05-01

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摘要： 目的探讨强制性功能训练对大鼠模型的神经传导束的影响。方法55只雌性SD大鼠随机分成两组:模型自然恢复(NR)组和模型强制训练(CIMT)组。CIMT组每天束缚健侧上肢强制进行滚筒、平衡木、网屏训练;NR组放在相同的自然环境下饲养。CIMT组在术后5d、10d、15d、30d、60d分别训练,行为学评分。最后的时间点各取5只大鼠,分别行核磁共振扫描,取大脑脚和脊髓进行髓鞘染色进行光镜观察。结果CIMT组的平衡能力、协调能力和患侧上肢的肌力较NR组恢复快(P<0.05)。CI-MT组患侧大脑脚和脊髓的神经纤维明显增粗,较少脱髓鞘,细胞数也略增多。结论CIMT训练可以最大限度地募集患侧存在功能的神经纤维(神经传导束),降低其脱髓鞘的神经传导束的数目。

关键词: 脑卒中, 康复, 强制性使用运动疗法(CIMT), 线栓模型, 行为学, 神经纤维

Abstract: Objective To study the effects of constraint-induced movement train (CIMT) on the neurological medullary sheath in the rats after middle cerebral artery occlusion (MCAO). Methods 55 SD rats were randomly divided into CIMT group and nature recovery (NR) group after MCAO. The CIMT group were trained with balance beam and rolling cage everyday, with restrictting the movement of the intact upper limbs. The NR group lived in the same condition. The rats in CIMT group were assessed with ethology 5 d, 10 d, 15 d, 30 d and 60 d after operation respectively. At last, 5 rats of each group were checked with MRI, then they were immolated for myelin staining. Results The balance and muscle strength of CIMT group improved better compared with the NR ones (P<0.05), as well as the diameter and the demyelination of neurofibril in the infarcted area. Conclusion CIMT can collect more functional neurofibra and decrease myelinolysis.

Key words: stroke, rehabilitation, constraint-induced movement therapy (CIMT), middle cerebral artery occlusion (MCAO), ethology, neurofibra