《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (04): 395-396.

• 临床研究 • 上一篇    下一篇

尿激酶介入治疗血管源性突发性耳聋疗效观察

唐立滨; 李唐英; 高良才; 孙继才; 张立杰   

  1. 唐山市人民医院耳鼻喉科,河北唐山市 063001
  • 收稿日期:2005-12-29 出版日期:2007-04-01 发布日期:2007-04-01

Effect of Interventional Therapy of Urokinase on Sudden Hearing Loss

TANG Li-bin, LI Tang-ying, GAO Liang-cai, et al   

  1. The Department of Otolaryngology, Tangshan People's Hospital, Tangshan 063001, Hebei, China
  • Received:2005-12-29 Published:2007-04-01 Online:2007-04-01

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摘要： 目的观察尿激酶介入治疗血管源性突发性耳聋的临床疗效。方法65例突发性耳聋患者分为治疗组35例和对照组30例,治疗组采用尿激酶经介入导管注入椎-基底动脉从而进入迷路动脉,改善内耳微循环,对照组采用传统静脉给药治疗。应用纯音测听等手段检查两组患者治疗前后的听力变化,比较疗效。结果治疗组21例听力恢复正常,12例听力提高15～30dB,2例提高<15dB;对照组10例恢复正常,4例提高15～30dB,9例提高<15dB,7例无明显变化,治疗组疗效优于对照组(P<0.05)。结论尿激酶介入治疗突发性耳聋效果优于传统静脉给药方法。

关键词: 突发性耳聋, 介入治疗, 尿激酶

Abstract: Objective To observe the effect of interventional therapy of urokinase on sudden hearing loss.Methods65 patients with sudden hearing loss were divided into the treatment group (n=35) and control group (n=30). The patients of the treatment group were treated with urokinase pouring into vertebral artery accordingly into labyrinthine artery in order to improve internal ear microcirculation. Those of the control group were treated with routine drug dropping in vein. All patients of two groups were examined by pure tone test before and after treatment and the therapeutic effect of two groups was compared.ResultsIn the treatment group, the audition of 21 cases recovered, 12 cases got 15～30 dB increasing, 2 cases increased <15 dB. In the control group, the audition of 10 cases recovered, 4 cases got 15～30 dB increasing, 9 cases increased <15 dB and 7 cases had no obvious improvement. There was a significant difference between effects of two groups ( P<0.05).ConclusionThe effect of urokinase on sudden hearing loss is superior to routine drug dropping in vein.

Key words: sudden hearing loss, interventional therapy, urokinase