《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (05): 394-395.

• 基础研究 • 上一篇    下一篇

成纤维细胞生长因子1基因启动子多态性与晚发型阿尔茨海默病的相关性研究

陈煜森1; 赵斌1; 许志恩1; 山県英久2; 三木哲郎2   

  1. 1.广东医学院附属医院神经内科 广东湛江市 524001;2.爱媛大学医学部老年医学 日本爱媛県791-0295
  • 收稿日期:2005-12-15 出版日期:2006-05-25 发布日期:2006-05-25

Correlation between the Promoter Polymorphism of Fibroblast Growth Factor 1 gene and Late-onset Alzheimer's Disease

CHEN Yu-sen, ZHAO Bin, XUZhi-en, et al   

  1. Department of Neurology, The Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, China
  • Received:2005-12-15 Published:2006-05-25 Online:2006-05-25

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摘要： 目的探讨成纤维细胞生长因子1(FGF-1)基因启动子多态性是否与晚发型阿尔茨海默病(LOAD)相关。方法收集206例尸体检查的样本,包括100例LOAD和年龄匹配的对照组106例。PCRRFLP(Restriction fragment length PolymorPhism)法分析FGF1基因启动子(-1385 A/G)的基因型。结果FGF1基因启动子(-1385 A/G)的基因型频率分布是:AA型20例(10%),GA型89例(43%),GG型97例(47%),在LOAD组和对照组之间,不同基因型频率分布有显著性差异(P=0.027);GG基因型与LOAD呈正相关(odds ratio=2.02,95% CI:1.16～3.52)。结论FGF1基因启动子(-1385 A/G)多态性与LOAD显著相关。

关键词: 晚发型阿尔茨海默病(LOAD), 成纤维细胞生长因子1(FGF-1)基因, 启动子多态性, 相关性

Abstract: ObjectiveTo evaluate the correlation between the promoter polymorphism of Fibroblast Growth Factor 1 (FGF-1) and late-onset Alzheimer's disease (LOAD). MethodsClinic pathological data from 206 autopsies were analyzed, including 100 autopsy-confirmed LOAD patients and 106 age-matched non-demented controls. PCR-RFLP (Restriction fragment length polymorphism) approach was used to determine the genotype of the promoter polymorphism of FGF-1 gene. ResultsThe genotyping frequencies of the promoter polymorphism (-1385 A/G) were AA 20 (10%), GA 89 (43%), GG 97 (47%), respectively. There was significant (P=0.027) difference of genotyping frequencies between the cases and controls; GG genotype was positively associated with LOAD (odds ratio=2.02, 95%CI:1.16～3.52). ConclusionThe promoter polymorphism (-1385 A/G) of FGF-1 gene was associated with LOAD.

Key words: late-onset Alzheimer's disease, fibroblast growth factor 1 (FGF-1) gene, promoter polymorphism, correlation