《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (04): 345-346.

• 临床研究 • 上一篇    下一篇

丙戊酸静脉制剂治疗儿童癫痫持续状态的疗效及安全性

戴津; 麦坚凝; 王秀英   

  1. 广州市儿童医院神经康复科 广东广州市 510120
  • 收稿日期:2005-09-19 出版日期:2006-04-25 发布日期:2006-04-25

Effect and Safety of Intravenous Sodium Valproate in Treatment of Pediatric Patients with Status Epilepticus

DAI Jin, MAI Jian-ning, WANG Xiu-ying   

  1. The Department of Neurology, GuangzhouChildren's Hospital, Guangzhou 510120, Guangdong, China
  • Received:2005-09-19 Published:2006-04-25 Online:2006-04-25

PDF (PC)

摘要： 目的探讨丙戊酸静脉制剂治疗儿童癫痫持续状态的疗效和安全性。方法对25例采用传统一线药物安定及苯巴比妥治疗无效的惊厥性癫痫持续状态住院患儿,改用丙戊酸静脉制剂以15mg/kg负荷量,1～2mg/kg维持量治疗,观察疗效及不良反应。结果丙戊酸静脉制剂治疗儿童癫痫持续状态总有效率92%,有7例患儿出现嗜睡,未见其他不良反应。结论丙戊酸静脉制剂治疗传统一线药物无效的儿童癫痫持续状态安全、有效。

关键词: 儿童, 丙戊酸静脉制剂, 癫痫持续状态

Abstract: ObjectiveTo explore the effect and safety of intravenous sodium valproate in treatment of pediatric patients with status epilepticus (SE).MethodsTwenty-five children suffering from convulsive SE were treated with intravenous sodium valproate after failure of the conventional treatment, in a dose of tolerability 15 mg/kg and 1～2 mg/kg daily.ResultsIn 25 cases, there were 23 cases (92%) with ≥50% seizure reduction and 11 cases (44%) with complete cessation. Except for winking in 7 cases (28%), no other adverse effects had been found.ConclusionIntravenous sodium valproate is effective and safe on pediatric patients with SE who are resistant to conventional drugs.

Key words: children, intravenous sodium valproate, status epilepticus