《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (04): 326-328.

• 临床研究 • 上一篇    下一篇

辛伐他汀对蛛网膜下腔出血严重并发症的影响

吴士文1; 马维娅1; 边红2; 杨光3; 章文斌4   

  1. 1.武警总医院神经内科 北京市 100039;2.山东医科大学附属济南中心医院神经内科 山东济南市 250013;3.徐州医学院附属淮安医院神经内科 江苏淮安市 223002;4.西安高新医院神经外科 陕西西安市 710054
  • 收稿日期:2006-01-23 出版日期:2006-04-25 发布日期:2006-04-25

Effect of Simvastatin on Severe Complications of Subarachnoid Heamorrhage

WU Shi-wen, MA Wei-ya, BIAN Hong, et al   

  1. The Department of Neurology, the General Hospital of Armed Police Force, Beijing 100039, China
  • Received:2006-01-23 Published:2006-04-25 Online:2006-04-25

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摘要： 目的探讨辛伐他汀对蛛网膜下腔出血严重并发症及其预后的影响。方法98例蛛网膜下腔出血患者随机分为治疗组和对照组(最终治疗组32例、对照组48例),治疗组给予辛伐他汀20mg/d;对照组予常规治疗,比较两组患者脑血管痉挛、脑积水和再出血的发生率,以及死亡率。结果治疗组脑积水发生率3.13%,与对照组的18.75%有显著性差异(P<0.05),而脑血管痉挛、再出血及死亡率与对照组无显著性差异(P>0.05)。结论辛伐他汀可以减少蛛网膜下腔出血后慢性脑积水的发生。

关键词: 辛伐他汀, 蛛网膜下腔出血, 脑血管痉挛, 脑积水

Abstract: ObjectiveTo investigate the effect of simvastatin on severe complications and prognosis of subarachnoid heamorrhage (SAH).Methods98 cases with SAH were randomly divided into the treatment groups and control group (finally, there were 32 cases in treatment group, 48 cases in control group). Patients in treatment group were given simvastatin 20 mg/day, and those in control group were treated with routine therapy. The incidences of cerebral vasospasm, hydrocephalus, rebleeding and mortality between the two groups were compared.ResultsThe incidence of hydrocephalus of treatment group was 3.13%; that of control group was 18.7%, there was a significantly difference between two groups (P<0.05). There were no significant differences for incidences of cerebral vasospasm, rebleeding and mortality between two groups (P>0.05).ConclusionSimvastatin can reduce the occurrence of hydrocephalus after SAH.

Key words: simvastatin, subarachnoid heamorrhage, cerebral vasospasm, hydrocephalus