《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (03): 270-272.

• 综述 • 上一篇    下一篇

糖尿病早期视网膜神经组织病理性改变研究进展

梁紫岩; 张卯年; 魏世辉   

  1. 中国人民解放军总医院眼科,北京市 100853
  • 收稿日期:2006-10-09 出版日期:2007-03-01 发布日期:2007-03-01

Neuronal and Glial Dysfunction before Diabetic Retinopathy (review)

LIANG Zi-yan, ZHANG Mao-nian, WEI Shi-hui   

  1. Department of Ophthalmology, General Hospital of PLA, Beijing 100853, China
  • Received:2006-10-09 Published:2007-03-01 Online:2007-03-01

摘要: 糖尿病视网膜病变(DR)是主要的致盲眼病。一直认为,视网膜微血管在糖尿病视网膜病理改变中发挥了主导作用。最近研究显示,在DR过程中有神经元的凋亡、神经胶质细胞功能障碍及视觉电生理等改变且先于视网膜微血管病变。本文综述近年来DR视网膜神经组织的国内外研究进展。

关键词: 糖尿病视网膜病变, 糖尿病, 神经胶质细胞, 神经变性, 细胞生物学, 视网膜电图

Abstract: Diabetic retinopathy is the leading cause of blindness in those of working age.It is well known that the retinal vasculature is altered during diabetes.More recently,it has emerged that neuronal,glial dysfunction and electroretinogram changes occur in those with diabetes.Current research is directed at understanding these neuronal and glial changes because they may be an early manifestation of disease processes that ultimately lead to vascular abnormality.This review will highlight the recent advances in our understanding of the neuronal,glial dysfunction,electroretiongram changes that occur during diabetes.

Key words: diabetic retinopathy, diabetes mellitus, glial cell, neurodegeneration, cellular biology, electroretinogram