《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (03): 205-207.

• 专题 脑梗死康复 • 上一篇    下一篇

氯胺酮脑保护作用研究进展

衣玉胜; 殷积慧   

  1. 青岛大学医学院附属医院麻醉科,山东青岛市 266003
  • 收稿日期:2006-11-17 出版日期:2007-03-01 发布日期:2007-03-01

Mechanism of Ketamine Protecting Brain from Ischemic Damage (review)

YI Yu-sheng, YIN Ji-hui   

  1. Department of Anesthesiology, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong, China
  • Received:2006-11-17 Published:2007-03-01 Online:2007-03-01

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摘要： 众多研究显示,氯胺酮对脑缺血缺氧性损伤具有保护作用。氯胺酮主要通过调节神经细胞凋亡;与N-甲基-D-门冬氨酸(NMDA)受体结合,抑制兴奋性氨基酸毒性及钙离子内流;抑制炎性因子生成和蛋白激酶表达等几个方面发挥脑保护作用。

关键词: 氯胺酮, 脑缺血, 脑保护, 综述

Abstract: Recently studies have shown that ketamine given to patients under mechanical ventilation and background anesthetics without adversely altering cerebral hemodynamics. More studies have also shown ketamine has neuroprotective effects. The main mechanisms may involve changing the expression of apoptosis-regulating proteins, inhibiting the toxicibility of excitatory amino acid and decreasing Ca2+ influx by blockade of NMDA receptors activation. It can also inhibit proinflammatory cytokine production induced by tissue ischemia and affect the protein kinase phosphorylations related to cerebral ischemia, etc..

Key words: ketamine, cerebral ischemia, neuroprotection, review