《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (03): 201-202.

• 专题 脑梗死康复 •    下一篇

山茱萸环烯醚萜苷对局灶性脑缺血模型大鼠神经功能和神经元损伤的影响

张丽1; 李春阳2; 赵玲1; 王文1; 张兰1; 李林1   

  1. 1.首都医科大学宣武医院药物研究室,教育部神经变性病学重点实验室,北京市 100053;2.内蒙古医学院第一附属医院神经内科,内蒙古呼和浩特市 010059
  • 收稿日期:2006-09-15 出版日期:2007-03-01 发布日期:2007-03-01

Effects of Cornel Iridoid Glycoside on Nervous Function and Neuron Damage in Focal Cerebral Ischemic Rats

ZHANG Li, LI Chun-yang, ZHAO Ling, et al   

  1. Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Education Ministry Key Laboratory for Neuro-Degenerative Disease, Beijing 100053, China
  • Received:2006-09-15 Published:2007-03-01 Online:2007-03-01

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摘要： 目的观察山茱萸环烯醚萜苷(CIG)对大脑中动脉阻塞法(MACO)致脑缺血再灌注模型大鼠神经功能和神经细胞的影响。方法用线栓法制备局灶性脑缺血大鼠模型,缺血2h再灌注24h。采用评分法检测神经功能改变,用尼氏染色的方法检测梗死灶神经元的变化。结果模型组与假手术组相比,神经症状评分明显升高,梗死灶神经元数量明显减少。与模型组相比,CIG灌胃口服能够明显降低模型大鼠神经症状评分,增加梗死灶神经元的存活数量。结论CIG对大鼠局灶性脑缺血有明显改善作用。

关键词: 山茱萸环烯醚萜苷, 脑梗死, 神经功能评分, 神经元存活

Abstract: Objective To observe the effects of cornel iridoid glycoside (CIG) on nervous function and neuronal survival in focal cerebral ischemic rat model.MethodsThe animal model was induced by occlusion of middle cerebral artery with suture embolus. Nervous function defect and survival number of neuron were detected with nervous function score and Nissl's staining respectively.ResultsCompared with Sham operation group, nervous function score increased and nervous survival number decreased obviously in model rats. Compared with model group, CIG decreased nervous function score and increased survival neurons significantly. ConclusionCIG may have theraputic effect on cerebral infarct through improving nervous function and increasing survival neurons.

Key words: cornel iridoid glycoside, cerebral infarct, nervous function score, neuronal survival