《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (02): 99-100.

• 专题 • 上一篇    下一篇

更昔络韦治疗脑瘫患儿巨细胞病毒感染疗效

李瑞花; 冯小伟; 黄鹦   

  1. 海南省人民医院儿科 儿童脑瘫康复中心 海南海口市 570311
  • 收稿日期:2005-12-14 出版日期:2006-02-25 发布日期:2006-02-25

Effect of Genciclovir on Cytomegalovirus Infection of Children with Cerebral Palsy

LI Rui-hua, FENG Xiao-wei, HUANG Ying   

  1. The Department of Pediatric, Children Cerebral Palsy Convalescent Center, People's Hospital of Hainan Provincial, Haikou 570311, Hainan, China
  • Received:2005-12-14 Published:2006-02-25 Online:2006-02-25

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摘要： 目的观察更昔络韦治疗脑瘫患儿巨细胞病毒(CMV)感染的疗效。方法36例感染CMV的脑瘫患儿随机分为治疗组和对照组各18例,治疗组应用更昔络韦,诱导期每次5mg/kg静滴,2次/d,持续14d,维持期每次7.5mg/kg,隔天1次,连用6周;对照组应用阿昔络韦,每次5mg/kg静滴,每8h1次,连用14d后改为每次7.5mg/kg静滴,每12h 1次,亦连用6周。检测两组患儿治疗前后尿中CMV-DNA含量的变化。结果尿中的CMV-DNA含量两组患儿治疗前无显著性差异(P>0.05);治疗后,对照组与治疗前相比无显著性差异(P>0.05),治疗组低于治疗前及对照组治疗后(P<0.05)。结论更昔络韦治疗脑瘫患儿CMV感染安全有效。

关键词: 更昔络韦, 脑性瘫痪, 治疗

Abstract: ObjectiveTo investigate the therapeutic effect of genciclovir on cytomegalovirus (CMV) infection of children with cerebral palsy (CP).Methods36 CP children with CMV infection were randomly divided into treatment group and control group with 18 cases in each group. Children of treatment group were treated by genciclovir with 5 mg/kg i.v. drip q l2 h for 14 days at inductive phase and 7.5 mg/kg i.v. drip qod for 6 weeks at maintain phase. Cases of control group were treated by acyclovir with 5 mg/kg i.v. drip q 8 h for 14 days at inductive phase and 7.5 mg/kg i.v. drip q l2 h for 6 weeks at maintain phase. CMV-DNA contents in urine of two groups were measured before and after treatment.ResultsCMV-DNA contents in urine of two groups were not different before treatment (P>0.05). For control group, CMV-DNA contents were also not different before and after treatment. For treatment group, CMV-DNA contents after treatment significantly decreased compared with pre-treatment and that of control group after treatment (P<0.05).ConclusionGenciclovir is effect and safety for CMV infection of CP children.

Key words: genciclovir, cerebral palsy, treatment