《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (02): 93-94.

• 专题 •    下一篇

免疫炎性因子过度表达在脑性瘫痪发病机制中的作用

孙杨1a; 文芳1b; 姚汉云1a; 郭焱2; 肖玲1b; 程自立1b; 万均成1b   

  1. 1.武汉大学人民医 a院神经科; b神经精神病研究所 湖北武汉市 430060;2.武汉市禧乐儿童康复中心 湖北武汉市 430070
  • 收稿日期:2005-12-14 出版日期:2006-02-25 发布日期:2006-02-25

Role of Overexpressed Proinflammatory Cytokines in the Pathogenesis of Cerebral Palsy

SUN Yang, WEN Fang, YAO Han-yun, et al   

  1. The Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China
  • Received:2005-12-14 Published:2006-02-25 Online:2006-02-25

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摘要： 目的探讨免疫炎性因子水平与脑性瘫痪发病机制的关系。方法运用ELISA法检测31名脑瘫患儿和20名健康儿童及37名脑瘫高危因素新生儿(新生儿病例组)和20名正常新生儿的血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的水平。结果脑瘫患儿和脑瘫高危因素新生儿的血清TNF-α和IL-6水平均高于健康儿童和正常新生儿(P<0.05);脑瘫患儿血清TNF-α水平高于脑瘫高危因素新生儿(P<0.05),IL-6水平两组间无显著性差异(P>0.05)。结论免疫炎性因子过度表达在脑性瘫痪的发病机制中发挥重要作用,高水平的免疫炎性因子可能是脑瘫发病的一个独立危险因素。

关键词: 脑性瘫痪, 免疫炎性因子, 免疫-神经-内分泌网络, 肿瘤坏死因子-α, 白细胞介素-6

Abstract: ObjectiveTo investigate the role of overexpressed proinflammatory cytokines in the pathogenesis of cerebral palsy (CP).MethodsLevels of tumor necrotic factor-α (TNF-α) and interleukin-6 (IL-6) in serum of 31 CP children, 20 healthy children (as controls), 37 neonates with CP risk factors such as hypoxic-ischemic injury and/or perinatal infection, and 20 healthy neonates (as controls) were measured by enzyme-linked immunosorbent assays (ELISA) retrospectively.ResultsLevels of TNF-α and IL-6 of CP children and neonates with CP risk factors were significantly higher than that of healthy controls (P<0.05). TNF-α level of CP children was significantly higher than that of neonates with CP risk factors (P<0.05), but there was no significant difference in IL-6 level between two groups.ConclusionOverexpressed proinflammatory cytokines play an important role in the pathogenesis of CP and may be an independent risk factor of CP.

Key words: cerebral palsy (CP), proinflammatory cytokines, immune-neuroendocrine network, tumor necrotic factor-α (TNF-α), interleukin-6 (IL-6)