《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (01): 72-73.

• 临床研究 • 上一篇    下一篇

超早期重组组织型纤溶酶原激活物溶栓治疗脑梗死的临床研究

李朝晖   

  1. 暨南大学医学院第三附属医院,广东珠海市 519000
  • 收稿日期:2006-08-06 出版日期:2007-01-01 发布日期:2007-01-01

Effect of Recombinant Tissue-type Plasminogen Activator on Hyperacute Cerebral Infarction

LIZhao-hui   

  1. the Third Hospital Affiliated to Jinan University Medical College, Zhuhai 519000, Guangdong, China
  • Received:2006-08-06 Published:2007-01-01 Online:2007-01-01

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被引次数

10

摘要： 目的探讨重组组织型纤溶酶原激活物(rt-PA)静脉溶栓治疗超早期脑梗死的安全性与有效性。方法按入选标准筛选合适患者21例进行溶栓,以相同时期非溶栓治疗的具有相同条件的患者20例为对照组,在溶栓前及溶栓后24h、21d按欧洲脑卒中神经功能缺损评分标准(ESS)进行评定,3个月时按Barthel指数进行评定。结果溶栓组疗效优于对照组(P<0.05)。溶栓组脑出血发生1例,预后仍然良好。两组患者均无死亡病例。结论rt-PA静脉溶栓治疗超早期急性脑梗死安全、有效。

关键词: 重组组织型纤溶酶原激活物(rt-PA), 静脉溶栓, 脑梗死

Abstract: ObjectiveTo study the efficacy and safety of intravenous recombinant tissue-type plasminogen activator (rt-PA) on hyperacute cerebral infarction. Methods41 patients with the supra-early acute cerebral infarction were divided into two groups: thrombolytic group (n=21) and control group (n=20). They were evaluated with European Stroke Scale (ESS) and Barthel Index before and 24 h, 21 d, 90 d after treatment. ResultsThe scores of the thrombolytic group showed more efficacious than that of the control groups (P<0.05). One patient suffered from cerebral hemorrhage in thrombolytic group, however his prognosis was good. There was no death in both groups. ConclusionThrombolytic therapy with rt-PA in the hyperacute cerebral infarction shows positive effect and safety.

Key words: recombinant tissue-type plasminogen activator (rt-PA), vein thrombolysis, cerebral infarction