《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (11): 915-916.

• 基础研究 • 上一篇    下一篇

运动训练对局灶性脑梗死大鼠梗死灶周围皮层p38表达的影响

贾子善1; 槐雅萍1; 翟金萍2; 何春年2   

  1. 1.河北省人民医院康复中心 河北石家庄市 050051;2.河北省人民医院病理科 河北石家庄市 050051
  • 收稿日期:2005-08-22 出版日期:2005-11-25 发布日期:2005-11-25

Effect of exercise on expression of p38 after cerebral infarction in rats

JIA Zi-shan,HUAI Ya-ping, ZAI Jin-ping, et al   

  1. Center of Rehebilitation, Hebei Provincial People's Hospital, Shijiazhuang 050051, Hebei, China
  • Received:2005-08-22 Published:2005-11-25 Online:2005-11-25

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摘要： 目的观察运动训练对脑梗死大鼠梗死灶周围皮层P38表达的影响。方法用Wistar大鼠制作大脑中动脉阻塞(MCAO)模型。48 h后随机分为3组:运动训练组、对照组、假手术组。运动组每天被动跑笼40 min。在MCAO后7、14、21和28d用免疫组化的方法检测梗死灶周围皮层P38的表达。结果梗死灶周围皮层P38表达增加(P<0.05),梗死后21 d及28 d,运动训练组梗死灶周围皮层P38表达明显高于非训练组(P<0.05)。结论脑梗死可诱发P38的表达,运动训练可增加其表达。

关键词: 脑梗死, 运动训练, 大鼠, 突触素

Abstract: ObjectiveTo study the effect of exercise on expression of p38 after cerebral infarction in rats.MethodsThe right middle cerebral artery was occluded(MCAO) with electric coagulation in Wistar rats,and then were divided into three groups at random 48 hours later: training group which were given wheel-running exercise everyday(n=20);control group(n=20) and sham group(n=10).The expression of p38 in cortex of the three groups were detected on 7th,14th,21th and 28th day after the MCAO.ResultsIn the cortex around the infarcted focus,the expressions of p38 elevated much significantly after cerebral infarction(P<0.05).The expression of p38 in training group were higher than those in control group(P<0.05) on the 21th and 28th day.ConclusionThe cerebral infarction could induce the expression of p38.The exercise could enhance its expression.

Key words: cerebral infarction, wheel-running exercise, rats, p38