《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (11): 895-896.

• 专题 • 上一篇    下一篇

托特罗定治疗脊髓损伤后逼尿肌反射亢进的临床观察

李东; 廖利民   

  1. 北京博爱医院泌尿外科 北京市 100068
  • 收稿日期:2005-10-13 出版日期:2005-11-25 发布日期:2005-11-25

Effects of tolterodine on detrusor hyperreflexia for patients with spinal cord injury

LI Dong, LIAO Li-min   

  1. Beijing Charity Hospital, Beijing 100068, China
  • Received:2005-10-13 Published:2005-11-25 Online:2005-11-25

PDF (PC)

被引次数

23

摘要： 目的评价抗胆碱能药物托特罗定治疗脊髓损伤后逼尿肌反射亢进的有效性和安全性。方法50例脊髓损伤后逼尿肌反射亢进患者口服托特罗定每日2次,每次2 mg,共治疗12周。观察治疗前后7 d排尿日记记录获得的数据。结果治疗12周后,患者平均功能性膀胱容量从(114.0±44.3)ml增加到(207.7±54.9)ml,24 h平均排尿次数从(8.9±2.7)次减少到(4.6±2.5)次,24 h平均尿失禁量从(646.7±348.9)ml减少到(426.6±291.3)ml,24 h平均尿失禁次数从(7.8±3.1)次减少到(4.8±3.2)次,均有非常显著性差异(P<0.05)。5例患者(10%)出现口干症状,但能耐受,未退出本研究。结论托特罗定是治疗脊髓损伤后逼尿肌反射亢进的安全有效药物。

关键词: 托特罗定, 脊髓损伤, 逼尿肌反射亢进

Abstract: ObjectiveTo evaluate the efficacy and tolerance of tolterodine in treating detrusor hyperreflexia in patients with spinal cord injury.Methods50 patients of spinal cord injury patients with detrusor hyperreflexia were involved in this study.The data from voiding diary were evaluated 7 days before and after the patients being treated with tolterodine 2 mg twice daily.ResultsAfter 12 weeks of treatment,the functional bladder volume increased from(114.0±44.3) ml to(207.7±54.9) ml,the mean frequency of micturition decreased from(8.9±2.7) /d to(4.6±2.5) /d,the mean volume of incontinence decreased from(646.7±348.9) ml to(426.6±291.3) ml,the mean frequency of incontinence decreased from(7.8±3.1) /d to(4.8±3.2) /d,which were all statistically different before and after treatment.5 patients felt dry mouth,but they could tolerated it.ConclusionTolterodine is an effective and well tolerable antimuscarinic agent for treating detrusor hyperreflexia after spinal cord injury.

Key words: tolterodine, spinal cord injury, detrusor hyperreflexia