《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (12): 1182-1183.

• 临床研究 • 上一篇    下一篇

硝酸甘油对高血压患者脉搏波速度的影响

张晏; 杨书文; 朱玲; 刘德平   

  1. 卫生部北京医院特需医疗部,北京市 100730
  • 收稿日期:2008-07-16 出版日期:2008-12-01 发布日期:2008-12-01

Effect of Nitroglycerin on Pulse Wave Velocity in Patients with Hypertension

ZHANG Yan, YANG Shu-wen, ZHU Ling, et al   

  1. The Department of Special-demand Medical Services, Beijing Hospital, Beijing 100730, China
  • Received:2008-07-16 Published:2008-12-01 Online:2008-12-01

PDF (PC)

摘要： 目的观察硝酸甘油对高血压患者脉搏波速度(PWV)的影响。方法将36例志愿者(年龄48.1±10.2岁)根据有无高血压病史分为高血压组和非高血压组,测定其基础状态下肱-踝PWV(BaPWV),然后给予硝酸甘油舌下含服,分别于给药后5min、10 min再次测定PWV。比较两组志愿者含药前后PWV的变化。结果含服硝酸甘油前,高血压组PWV均值为右侧(1672±202)cm/s、左侧(1681±204)cm/s,非高血压组分别为(1467±221)cm/s和(1470±232)cm/s。基础状态下高血压组PWV速度高于非高血压组(P<0.05)。舌下含服硝酸甘油后5 min、10 min高血压组和非高血压组的PWV速度均明显降低(均为P<0.01),但10 min时的PWV较5 min时的明显升高(P<0.01)。含药后无论5 min或10 min时的PWV,高血压组均高于非高血压组(均为P<0.05)。结论硝酸甘油可以降低高血压患者的BaPWV。

关键词: 脉搏波速度, 硝酸甘油, 动脉僵硬度

Abstract: Objective To observe the effect of nitroglycerin(NTG) on pulse wave velocity(PWV) in patients with hypertension(HTN).Methods36 volunteers,mean age 48.1±10.2 years,were divided into HTN group and non-hypertension(NHTN) group according to whether he or she had hypertension or not.The baseline PWV and PWV at 5th minute and 10th minute after sublingual NTG were detected.PWVs of the two groups were compared.ResultsThe basal PWV in HTN group was higher than that in NHTN group.PWV was reduced significantly after NTG were given sublingually 5 minutes or 10 minutes compared with baseline condition(both P<0.01).PWV 10 minutes after sublingual NTG raised a little compared with that after 5 minutes(P<0.01).PWVs 5 minutes or 10 minutes after sublingual NTG in HTN group were higher than those in NHTN group(both P<0.05).ConclusionNTG can reduce PWV in patients with HTN.

Key words: pulse wave velocity, nitroglycerin, arterial stiffness