《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (12): 1173-1176.

• 临床研究 • 上一篇    下一篇

A型肉毒毒素缓解脑瘫儿童小腿三头肌痉挛最佳剂量研究

刘建军; 纪树荣; 胡莹媛; 吴卫红; 李燕春; 陆华宝; 张雁   

  1. 1.首都医科大学康复医学院,北京市 100068;2.中国康复研究中心北京博爱医院,北京市 100068
  • 收稿日期:2007-07-19 出版日期:2008-12-01 发布日期:2008-12-01

Optimal Dose of Botulinum Toxin A to Release Spasticity of Triceps Surae in Children with Cerebral Palsy

LIU Jian-jun, JI Shu-rong, HU Ying-yuan, et al   

  1. CapitalMedical University School of Rehabilitation Medicine, BeijingCharity Hospital, ChinaRehabilitation Research Center, Beijing 100068, China
  • Received:2007-07-19 Published:2008-12-01 Online:2008-12-01

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摘要： 目的确定治疗脑瘫痉挛的理想A型肉毒毒素(BTX-A)剂量计算公式中的系数。方法将58例脑瘫患儿(男性38例、女性20例,年龄27～144个月,平均59.3±24.6个月)按剂量系数分为A、B、C、D、E五组,给予不同剂量的BTX-A治疗。结果从运动功能改善的角度考虑,D组的BTX-A剂量比较适合;从疗效持续时间的角度考虑,C组的BTX-A剂量比较适合,理想的系数应为1.8。结论小腿三头肌初次BTX-A理想剂量的计算公式应为:剂量(I U)=(1+1.8×MAS评分)×体重(kg)。

关键词: 脑性瘫痪, 痉挛, A型肉毒毒素, 神经阻滞, 剂量

Abstract: Objective To determine the coefficient in the formula of the optimal dose of botulinum toxin A(BTX-A) to treat spastic cerebral palsy(CP).Methods58 CP children(male 38,female 20,mean age 59.3±24.6 months,range 27 to 144 months) were divided into A,B,C,D and E five groups according to used coefficient and treated by BTX-A with different doses to release the spasticity.ResultsAccording to the improvement of motor function,the BTX-A dose of the group D was optimal.According to the effective endurance,the BTX-A dose of the group C was optimal.The optimal coefficient was 1.8.ConclusionThe formula of the optimal BTX-A dose injected in triceps surae is dose =(1+1.8×MAS score)×body weight.

Key words: cerebral palsy, spasm, botulinum toxin A(BTX-A), nerve block, dose