《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (12): 1139-1140.

• 基础研究 • 上一篇    下一篇

不同压力和部位压迫大鼠坐骨神经对神经血流量的影响

高月明1a; 王兴林1a; 张立宁1a; 索伟1a; 蒋天裕1a; 赵秀梅1b   

  1. 1.解放军总医院a.理疗科;b.病理生理室,北京市 100853
  • 收稿日期:2008-05-19 出版日期:2008-12-01 发布日期:2008-12-01

Effect of Sciatic Nerve Compression with Different Pressures and Sites on Neural Blood Flow in Rats

GAO Yue-ming, WANG Xing-lin, ZHANG Li-ning, et al   

  1. The Department of Physical Therapy, General Hospital of PLA, Beijing 100853, China
  • Received:2008-05-19 Published:2008-12-01 Online:2008-12-01

摘要: 目的观察受压迫坐骨神经在不同压力条件下以及不同部位压迫时神经血流量的变化。方法建立可同时控制压力时间的大鼠坐骨神经卡压模型,应用气囊分5级压力压迫大鼠坐骨神经,观察不同压力下神经血流量的变化;将大鼠随机分为远端压迫组和近端压迫组,观察不同部位压迫神经对神经血流量的影响。结果不同压力压迫神经时神经血流量产生变化(P<0.05),并且随着压力增高神经血流量出现下降趋势;近端压迫组和远端压迫组神经血流量均明显下降(P<0.01),但后者的神经血流量下降较前者明显(P<0.01)。结论机械压迫神经对神经血流量影响明显,坐骨神经远端血管是神经血供的主要来源。

关键词: 坐骨神经, 神经血流量, 激光多谱勒血流仪, 神经卡压模型

Abstract: Objective To observe the changes of neural blood flow when oppressed with different pressures and at different sites in rat's sciatic nerve.MethodsThe sciatic nerve compression model of rat with pressure and time controlled simultaneously was established.The changes of neural blood flow were observed by oppressing the sciatic nerve with five grades pressures using Gasbag.The rats were randomly divided into the distal compression group and proximal compression group,and the changes of neural blood flow were observed in each group.ResultsThe neural blood flow changed significantly(P<0.05) when the sciatic nerve was oppressed with different pressures and it had the decreasing tendency with the pressures increasing.The neural blood flow of each group decreased obviously(P<0.01).The effect of oppressing distal nerve on neural blood flow was more obvious than that of oppressing proximal nerve(P<0.01).ConclusionMechanical compression can influence the neural blood flow obviously.The distal vessels of sciatic nerve are the major sources of nerve blood supply.

Key words: sciatic nerve, neural blood flow, laser Doppler flowmetry, nerve compression model