《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (10): 834-837.

• 临床研究 • 上一篇    下一篇

帕金森病MRI白质高信号研究

朱珍; 耿道颖; 沈黎玮; 吴晓琰   

  1. 复旦大学附属华山医院放射科; 复旦大学附属华山医院经内科
  • 收稿日期:2005-04-13 出版日期:2005-10-25 发布日期:2005-10-25

Study of white matter hyperintensities of Parkinson's disease by MRI

ZHU Zhen, GENG Dao-ying, SHEN Li-wei, et al   

  1. The Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200032, China
  • Received:2005-04-13 Published:2005-10-25 Online:2005-10-25

摘要: 目的探讨帕金森病(PD)常规MRI检查白质高信号(WMH)与临床的关系。方法分析64例PD患者和45例健康老年人对照组常规MRI检查WMH、脑室周高信号(PVH)、深部白质高信号(DWMH)和年龄、病程、分级的关系。结果PD患者WMH发生率较对照组增高,但无显著性差异(P>0.05),有WMH的PD患者较无WMH的患者年龄更大(P<0.01),病情更严重(P<0.01)但病程无显著性差异(P>0.05);PD组DWMH发生率较对照组略高,但无显著性差异(P>0.05);有DWMH的PD患者较无DWMH的患者年龄更大(P<0.01),但病程、病情严重程度无显著性差异(P>0.05);PD组PVH发生率较对照组增高,有显著性差异(P<0.05),有PVH的PD患者较无PVH的患者年龄更大(P<0.01),病情更严重(P<0.01),但病程无显著性差异(P>0.05);PD患者和对照组的DWMH分级无显著性差异(P>0.05),但PVH分级有显著性差异(P<0.05)。结论PVH与PD的一些临床特征有关,PVH可能会影响病情的严重程度。

关键词: 帕金森病, 磁共振成像, 白质

Abstract: ObjectiveTo explore the correlation between white matter hyperintensities(WMH) and the clinical features of Parkinson's disease(PD) when examined by magnetic resonance imaging(MRI).MethodsThe correlation between WMH,periventricular hyperintensities(PVH),deep white matter hyperintense signals(DWMH) in MRI and age,disease duration,distribution in 64 patients with PD and 45 age-matched healthy controls was studied.ResultsThe frequency of WMH was higher in patients with PD,but no significant difference compared with controls(P>0.05).The patients with WMH were significantly older(P<0.01) and more severity(P<0.01) than those without WMH,but disease duration was no significant difference(P>0.05).The frequency of DWMH was higher in patients with PD,but no significant difference compared with controls(P>0.05).The patients with DWMH were significantly older(P<0.01) than those without DWMH,but disease duration and severity were no significant difference(P>0.05).The frequency of PVH was higher in patients with PD and having a significant difference compared with controls(P<0.05).The patients with PVH were significantly older(P<0.01) and more severity than those without PVH,but disease duration was no significant difference(P>0.05).The distribution of DWMH was not significantly different between patients with PD and controls (P>0.05),but distribution of PVH was significantly different between patients with PD and controls(P<(0.05)).ConclusionPVH may influence some clinical features of PD characterized by a greater disease severity.

Key words: Parkinson's disease, magnetic resonance imaging(MRI), white matter

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