《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (10): 790-792.

• 专题 • 上一篇    下一篇

补体成分3与脑梗死早期进展间的关系

陈黔妹; 沈扬; 樊东升; 曹贵方; 夏一鲁; 董春萍; 杨春祥; 董文翊; 何雯   

  1. 清华大学第一附属医院神经内科 北京市 100016;北京大学第三医院神经内科 北京市 100083
  • 收稿日期:2005-03-28 出版日期:2005-10-25 发布日期:2005-10-25

Relationship between complement-3 and progression of early cerebral infarction

CHEN Qian-mei, SHEN Yang, FAN Dong-sheng,et al   

  1. The Department of Neurology, The First Hospital of Hsinghua University, Beijing 100016, China
  • Received:2005-03-28 Published:2005-10-25 Online:2005-10-25

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摘要： 目的探讨补体成分3(C3)与缺血性进展性卒中间的关系。方法对168例发病24 h内续贯住院的脑梗死患者进行前瞻性研究。在入院后第2天或第3天晨抽取静脉血检测血浆C3及其他生化指标,进行单因素及Logistic多元回归分析,了解C3与进展性卒中之间的关系。结果68例患者(40.48%)在住院72 h内病情进展,进展性卒中患者血浆C3水平为(1.28±0.20)g/L,明显高于非进展性卒中患者的(1.16±0.25)g/L(P=0.000);随C3水平的升高,进展性卒中的发生率呈明显升高趋势(P=0.001)。Logistic回归分析显示,C3与进展性卒中呈明显相关(OR=7.247;95%CI=1.52～36.39;P=0.013)。结论C3升高在进展性脑卒中的发病中可能具有重要意义。

关键词: 脑梗死, 进展性卒中, 补体成分3

Abstract: ObjectiveTo investigate the relationship between complement-3(C3) and progression of early cerebral infarction.Methods168 consecutive patients with acute cerebral infarction within the first 24 hours from onset were recruited.Fasting venous blood sample was drawn on the morning of the second or the third day after admission.C3 and other clinical chemistry variables were measured.The relationship of C3 and progressing stroke(PS) was analyzed by Logistic regression.Results68 cases(40.48%) were considered as PS.Level of serum C3 in PS patients was 1.28±0.20 g/L higher than in those with non-PS(1.16±0.25 g/L,P=(0.000)).A higher C3 accompanied a higher tendency of prevalence of PS(P=0.001).Logistic regression analysis showed that C3 was significantly correlated with PS(OR for each 1.0 g/L=7.27;95% CI=1.52～36.39; P=0.013).ConclusionElevated serum C3 may play an important role in the prevalence of PS.

Key words: cerebral infarction, progressing stroke, complement-3(C3)