《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (10): 783-786.

• 专题 • 上一篇    下一篇

体感诱发电位在脑通口服液治疗大鼠急性脑梗死中的应用

王益光; 李志坚; 王忠伟; 唐可欣; 王玉良; 李文涛   

  1. 潍坊医学院生理学教研室 山东潍坊市 261042
  • 收稿日期:2005-05-19 出版日期:2005-10-25 发布日期:2005-10-25

Effects of Naotong oral solution on acute cerebral infarction in rats

WANG Yi-guang, LI Zhi-jian, WANG Zhong-wei, et al   

  1. The Department of Physiology, Weifang Medical College, Weifang 261042, Shandong, China
  • Received:2005-05-19 Published:2005-10-25 Online:2005-10-25

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摘要： 目的观察脑通口服液(NT)对急性脑梗死大鼠体感诱发电位(SEP)的影响及其疗效。方法24只脑梗死模型大鼠随机分为3组,分别用NT、脑血康口服液(NXK)和生理盐水(NS)灌服治疗20 d,于治疗前后观察动物的SEP和神经病学评分改变。结果与治疗前比较,NT组大鼠所有SEP波及NXK组部分SEP波潜伏期缩短(P<0.01);NT和NXK组大鼠治疗后神经病学评分均降低(P<0.05),且低于NS对照组组(P<0.05);模型大鼠SEP潜伏期与神经病学评分呈高度正相关(r=0.97～0.99;P<0.05～0.01)。结论脑通口服液可明显促进急性脑梗死大鼠神经功能的恢复;SEP可用于急性脑梗死的疗效观察。

关键词: 脑通口服液, 脑梗死, 体感诱发电位, 大鼠

Abstract: ObjectiveTo observe effects of Naotong(NT) oral solution on the somatosensory evoked potentials(SEP) of acute cerebral infarction rats and its curative experimental.Methods24 model rats were randomly divided into three groups and treated with NT oral solution,Naoxuekang(NXK) and normal saline(NS) respectively for 20 days,the SEP and neurologic grades of the rat models were evaluated before and after treatment.ResultsAll the latencies of SEP(P1,N2,P2) in NT group was shorter than that of the pre-treatment and NS control group(P<0.01).The neurologic grades of both NT and NXK groups were highly lowered compared with pre-treatment and NS control group(both P<0.05).The latencies of SEP in the model rats were highly correlated with the neurologic grades(r=0.97～0.99,P<0.05～0.01).ConclusionNT can accelerate the nervous function recovery of the rat models with acute cerebral infarction.SEP may be used as a powerful index of observation on curative effect of acute cerebral infarction.

Key words: Naotong oral solution, cerebral infarction, somatosensory evoked potentials(SEP), rat