《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (10): 781-782.

• 专题 •    下一篇

抗窄1号对实验性大鼠颈动脉血管成形术后再狭窄的病理学影响

薛金贵; 王肖龙; 胡婉英; 高俊杰; 唐靖一   

  1. 上海中医药大学附属曙光医院心血管科 上海市 200021
  • 收稿日期:2005-05-17 出版日期:2005-10-25 发布日期:2005-10-25

Pathological effect of Anti-stenosis No.1 on restenosis after carotid artery angioplasty in experimental rats

XUEJin-gui, WANG Xiao-long, HU Wan-ying, et al   

  1. The Department of Cardiovascular, Shanghai University of TCM Affiliated Shuguang Hospital, Shanghai 200021, China
  • Received:2005-05-17 Published:2005-10-25 Online:2005-10-25

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摘要： 目的探讨自拟益气活血、化痰通络的抗窄1号方对大鼠颈动脉血管成形术后再狭窄的病理学影响。方法48只大鼠随机分为空白对照组(假手术组)、高脂组、中药大、小剂量组,采用高胆固醇饲料喂养配合3次球囊损伤颈动脉内膜方法建立大鼠血管成形术后再狭窄模型,中药喂养3个月。观察再狭窄部位管腔面积、内、中膜面积、内膜/中膜比值。结果与空白对照组比较,高脂组、中药小剂量组和大剂量组的管腔面积、内膜面积均有明显改变(P<0.01),高脂组和中药小剂量组中膜面积、内膜/中膜比值有明显改变(P<0.01),大剂量组无明显变化;与高脂组相比较,中药大剂量组管腔面积明显增大(P<0.01),大、小剂量组内膜面积均减少(P<0.05),大剂量组中膜面积明显减少(P<0.01);小剂量组的中膜面积与大剂量组有显著性差异(P<0.05)。结论中药抗窄1号可通过抑制动脉内、中膜增殖,抑制再狭窄的发生,且抑制作用呈剂量依赖性。

关键词: 抗窄1号, 大鼠, 颈动脉, 再狭窄

Abstract: ObjectiveTo explore the pathological effect of Anti-stenosis No.1 which had effect of vivid Qi and promoting blood flow,eliminate sputum and circulating collaterals on restenosis after carotid artery angioplasty in experimental rats.Methods48 rats were randomly divided into the blank group,the hyperlipid group,the small-dose group and the large-dose group.Restenosis model in carotid artery after angioplasty was built by high-dose cholesterol diet and three times balloon injury.Chinese herbs were administered for three months.Lumen area,intimal area,media area and intimal area/media area in the restenosis region were calculated.ResultsLumen area and intimal area were very more significantly changed in the hyperlipid group,the small-dose group,and the large-dose group compared to the blank group(P<0.01).Media area and intimal area/media area were very more significantly changed in the hyperlipid group and the small-dose group compared to the blank group(P<0.01).There was no significant difference in the large-dose group.Compared to hyperlipid group,lumen area significantly increased in the large-dose group(P<0.01)),intimal area significantly decreased in the small-and large-dose groups(P<0.05),and media area significantly decreased in the large-dose group(P<0.01).There was a significant difference in media area between the small-and large-dose groups(P<0.05).ConclusionAnti-stenosis No.1 can significantly inhibit restenosis by inhibiting intimal and media hyperplasty,and the effect is dose dependent.

Key words: Anti-stenosis No.1, rats, caotid artery, restenosis