《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (08): 656-657.

• 临床研究 • 上一篇    下一篇

丙氨酰谷氨酰胺双肽对胃癌患者术后免疫功能的影响

郑建勇; 王为忠; 管文贤; 陈冬利; 张崇广   

  1. 1.第四军医大学西京医院普二科 陕西西安市 710032;2.武警北京部队医院外一科 北京市 100027
  • 收稿日期:2005-05-23 出版日期:2005-08-25 发布日期:2005-08-25

Effect of alanyl-glutamine on immune function of patients with gastric cancer

ZHENG Jian-yong, WANG Wei-zhong, GUAN Wen-xian, et al   

  1. The Department of Gastrointestinal Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, Shanxi, China
  • Received:2005-05-23 Published:2005-08-25 Online:2005-08-25

PDF (PC)

摘要： 目的观察添加丙氨酰谷氨酰胺双肽的全肠外营养(TPN)对胃癌术后患者免疫功能的影响。方法进展期胃癌根治性切除患者50例,随机分为对照组和试验组,对照组采用常规TPN,试验组在常规TPN基础上加用丙氨酰谷氨酰胺双肽注射液。术后第1天开始对两组患者行肠外营养支持,时间1周。于术前及术后第1天、第8天分别抽取外周血测定IgG、IgA、IgM和T淋巴细胞亚群CD3、CD4、CD8,及CD4/CD8比值。结果术后第1天,两组患者的各项免疫指标均有所下降;术后第8天,试验组的各项免疫指标均有所恢复,其中IgG、IgM、IgA、CD3、CD4和CD4/CD8比值与对照组有显著性差异(P<0.05)。两组患者在观察期间均无严重并发症。结论含丙氨酰谷氨酰胺双肽的全肠外营养能有效改善和增强胃癌患者术后机体的免疫功能。

关键词: 肠外营养, 丙氨酰谷氨酰胺, 胃癌, 免疫功能

Abstract: ObjectiveTo investigate the effect of alanyl-glutamine supplemented total parenteral nutrition (TPN) on immune function of patients with gastric cancer.MethodsFifty gastric cancer patients with radical gastrectomy were randomly divided into the control group (n=25) and experiment group (n=25). Patients in the control group received conventional TPN support, and patients in the experiment group received TPN support and alanyl-glutamine (0.34 g/kg). All patients were observed for 7 days. The levels of IgG, IgA, IgM, CD3, CD4, CD8 and CD4/CD8 were measured before operation and on first and eighth day after operation.ResultsAll the levels of immune function were decreased on first day after operation in two groups. But the levels of IgG, IgA, IgM, CD3, CD4 and CD4/CD8 were significantly different between two groups on eighth day after operation (P<0.05). No serious infectious complication occurred in both groups.ConclusionTPN supplemented with alanyl-glutamine can improve the immune function of patients with gastric cancer radical gastrectomy.

Key words: parenteral nutrition, alanyl-glutamine, gastric cancer, immune function