《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (10): 932-933.

• 基础研究 • 上一篇    下一篇

运动和饮食因素对脑老化小鼠学习记忆能力影响的行为学观察

肖忠新; 云少君; 贺晓娟; 蒋卫; 贺恺文; 魏守刚   

  1. 首都医科大学公共卫生与家庭医学学院,北京市 100069
  • 收稿日期:2008-06-27 出版日期:2008-10-01 发布日期:2008-10-01

Behavior Observation on Learning and Memory Ability of Brain Aging Mice Intervened by Exercise and Diet

XIAO Zhong-xin, YUN Shao-jun, HE Xiao-juan, et al   

  1. Capital Medical University School of Public Health and Family Medicine, Beijing 100069, China
  • Received:2008-06-27 Published:2008-10-01 Online:2008-10-01

PDF (PC)

被引次数

3

摘要： 目的观察高脂饮食和运动对D-半乳糖(D-gal)致脑老化小鼠学习记忆功能的影响。方法采用D-gal致脑老化复制脑老化小鼠模型,以Morris水迷宫测试小鼠学习记忆功能。结果高脂饲料脑老化模型组与普通饲料脑老化模型限食组、普通饲料脑老化模型加运动组、高脂饲料脑老化模型加运动组、高脂饲料正常组、普通饲料加运动组、普通饲料正常组之间学习记忆功能的差异均有统计学意义(P<0.05);空间探索试验显示,普通饲料脑老化模型限食组与普通饲料脑老化模型组之间的差异有统计学意义(P<0.05)。结论运动和限食可减轻脑老化小鼠学习记忆能力的下降;高脂饮食有促进脑老化的作用。

关键词: 高脂, 脑老化, 学习记忆, Morris水迷宫

Abstract: Objective To observe effects for exercise and diet on learning and memory ability in mice with encephalon aging induced by D-galactose(D-gal).Methods The model of mice with encephalon aging was made by D-gal.The learning and memory ability of mice was determined by Morris water maze.Results There was significant difference between high fat feed encephalon aging group and restrict food on normal feed encephalon aging group,normal feed and exercise encephalon aging group,high fat feed and exercise encephalon aging group,high fat feed normal group,normal feed and exercise group,normal feed group(all P<0.05).In spatial probe test,there was significant difference between restrict food on normal feed encephalon aging group and normal feed encephalon aging group(all P<0.05).Conclusion Exercise and restrict food can improve the learning and memory function in the mice;feed with high fat can promote encephalon aging.

Key words: high fat, encephalon aging, learning and memory, Morris water maze