《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (07): 568-569.

• 临床研究 • 上一篇    下一篇

慢性阻塞性肺疾病长期机械通气患者血清睾酮、CD4+/CD8+ T细胞的变化

孙宝君1; 赵红梅2; 邹琳1; 刘长庭1; 俞森洋1   

  1. 1.解放军总医院南楼呼吸科 北京市 100853;2.北京博爱医院内科 北京市 100068
  • 收稿日期:2005-05-29 出版日期:2005-07-25 发布日期:2005-07-25

Change of testosterone and CD4+/CD8+ T cell in long-term mechanical ventilation patients with chronic obstructive pulmonary disease

SUN Bao-Jun,ZHAO Hong-mei,ZOU Lin,et al   

  1. Department of Respiration, Building Nan, General Hospital of PLA,Beijing 100853, China
  • Received:2005-05-29 Published:2005-07-25 Online:2005-07-25

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摘要： 目的初步研究长期机械通气慢性阻塞性肺疾病(COPD)患者血清睾酮和CD4+/CD8+T细胞的变化,及其相关性。方法长期机械通气COPD患者42例为研究组,稳定期COPD患者34例为对照组,进行血清睾酮检测,流式细胞仪检测CD4+、CD8+T细胞,并计算其相关性。结果研究组血清睾酮水平、CD4+/CD8+T细胞比例均低于对照组(P<0.05),但血清睾酮与CD4+/CD8+T细胞比之间无相关性(P>0.05)。结论长期机械通气COPD患者血清睾酮、CD4+/CD8+T细胞比明显降低,但两者间无相关性。

关键词: 肺疾病, 慢性阻塞性, 机械通气, 老年, 血清睾酮, CD4, CD8, T细胞

Abstract: ObjectiveTo investigate the change of the level of testosterone and CD4+/CD8+ T cell in long-term mechanical ventilation patients with chronic obstructive pulmonary disease (COPD) and their correlation.MethodsThe level of testosterone, count of CD4+ and CD8+ T cell were measured in 42 COPD patients accepted long-term mechanical ventilation and other 34 stable COPD patients. The ratio of CD4+/CD8+ was calculated.The correlation between testosterone and CD4+/CD8+ was analyzed.ResultsCompared with the stabel COPD, there were significantly differences in the level of testosterone and the ratio of CD4+/CD8+ in long-term mechanical ventilation COPD group(P<0.05), but there was not relationship between them.ConclusionThe level of testosterone and the ratio of CD4+/CD8+ were significantly decreased in COPD patients with long-term mechanical ventilation. There is no correlation between the level of testosterone and the ratio of CD4+/CD8+.

Key words: lung disease, chronic obstructive, elderly, mechanical ventilation, testosterone, CD4, CD8, T cell