《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (10): 912-914.

• 专题 • 上一篇    下一篇

运动诱导海马内IGF-1的变化与学习记忆能力的关系

孟兆辉1; 徐波1; 李世昌1; 黄涛2; 于海珍1   

  1. 1.华东师范大学体育与健康学院,上海市 200241;2.井冈山大学体育学院,江西吉安市 343009
  • 收稿日期:2008-04-30 出版日期:2008-10-01 发布日期:2008-10-01

Relationship between Changes of Exercise Induced Insulin-like Growth Factor-1 in Hippocampus and Ability of Learning Memory(review)

MENG Zhao-hui,XUBo,LI Shi-chang,et al   

  1. School of Physical Education and Health, East China Normal University,Shanghai 200241, China
  • Received:2008-04-30 Published:2008-10-01 Online:2008-10-01

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摘要： 近年来的研究显示,胰岛素样生长因子-1(IGF-1)与学习记忆密切相关;运动可以使海马内的IGF-1水平升高;IGF-1可能介导运动促进学习记忆的过程,其机制之一可能是IGF-1和脑源性神经营养因子(BDNF)信号通路对Ca2+/钙调蛋白依赖性蛋白激酶Ⅱ(CAMKⅡ)、丝裂原活化蛋白激酶Ⅱ(MAPKⅡ)和突触素-1起调节作用,它们共同调节突触的可塑性,进而提高学习记忆能力。

关键词: 运动, 胰岛素样生长因子-1, 学习记忆, 海马, 综述

Abstract: Recent study demonstrated that insulin-like growth factor-1(IGF-1) could have benefits to improve the learning memory.Exercise can increase IGF-1 level in hippocampus.IGF-1 may mediate exercise inducing learning memory;one of the possible mechanism is that the IGF-1 and brain derived neurotrophic factor(BDNF) has a common regulatory capacity over calcium/calmodulin-dependent protein kinase Ⅱ(CAMKⅡ),mitogen-activated protein kinase Ⅱ(MAPKⅡ) and synapsin-1,and the convergence of multiple signaling pathways mediate synaptic plasticity and improve learning memory.

Key words: exercise, insulin-like growth factor-1, learning memory, hippocampus, review