《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (10): 907-909.

• 专题 • 上一篇    下一篇

脑缺血/缺氧预适应相关蛋白质及其功能研究进展

刘莉莉1; 苏吉亮1 综述; 牛敬忠2 审校   

  1. 1.山东泰山慢性病医院,山东泰安市 271000;2.泰山医学院附属医院神经内科,山东泰安市 271000
  • 收稿日期:2008-06-17 出版日期:2008-10-01 发布日期:2008-10-01

Advance in Research on Proteins Related with Brain Ischemia/Hypoxia Preconditioning and Their Functions(review)

LIULi-li, SU Ji-liang, NIU Jing-zhong   

  1. Taishan Chronic Disease Hospital, Tai'an 271000, Shandong, China
  • Received:2008-06-17 Published:2008-10-01 Online:2008-10-01

PDF (PC)

被引次数

7

摘要： 脑缺血/缺氧预适应(I/HPC)是机体抗缺血缺氧的一种内源性保护现象。研究显示,低氧诱导因子-1(HIF-1)、热休克蛋白(HSPs)、促红细胞生成素(EPO)、Bcl-2家族、降钙素基因相关肽(CGRP)等多种蛋白质参与脑I/HPC,作者就这些蛋白质的功能及参与I/HPC的机制作一阐述。

关键词: 脑缺血/缺氧预适应, 低氧诱导因子-1, 热休克蛋白, 促红细胞生成素, 功能, 综述

Abstract: Brain ischemia/hypoxia preconditioning(I/HPC) is one kind of endocardial protective phenomenon by organism against blood and oxygen deficit.Researches discovered various proteins such as hypoxic inducible factor-1(HIF-1),heat shock proteins(HSPs),erythropoietin(EPO),Bcl-2 family,calcitoningene related peptide(CGRP) and so on participated in brain I/HPC.This essay explains function and participating I/HPC mechanism of these proteins.

Key words: brain ischemia/hypoxia preconditioning, hypoxic inducible factor-1, heat shock protein, erythropoietin, function, review