《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (07): 546-547.

• 基础研究 • 上一篇    下一篇

Clenbuterol对大鼠脊髓损伤后运动功能恢复作用研究

张岩; 李艺影; 赵继宗; 王硕; 刘相名   

  1. 1.北京天坛医院神经外科 北京市 100050;2.北京市神经外科研究所 北京市 100050
  • 收稿日期:2005-06-13 出版日期:2005-07-25 发布日期:2005-07-25

Study of effect of clenbuterol,a β2-adrenoceptor agonist on the recovery of locomotor function following spinal cord injury in rats

ZHANG Yan, LI Yi-ying, ZHAO Ji-zong, et al   

  1. Department of Neurosurgery, Beijing Tiantan Hospital,Capital University of Medical Science, Beijing 100050,China
  • Received:2005-06-13 Published:2005-07-25 Online:2005-07-25

PDF (PC)

被引次数

6

摘要： 目的探讨肾上腺素能β2受体激动剂Clenbuterol对脊髓损伤后运动功能恢复的作用。方法重力冲击方法建立大鼠胸髓(T10)损伤动物模型,以不同高度确立试验组。根据Basso-Beattie-Bresnahan(BBB)评分标准评测运动功能情况。试验动物存活6周,进行挫伤脊髓的组织形态学观察。结果Clenbuterol治疗组的平均BBB分值为(10.0±2.1),而对照组分值为(6.3±1.5),P<0.05。Clenbuterol治疗组周边组织残存区面积明显大于对照组。结论在脊髓损伤后应用肾上腺素能β2受体激动剂Clenbuterol可保护脊髓残存的神经组织,帮助改善运动功能的恢复。

关键词: Clenbuterol, 脊髓损伤, 运动功能, 肾上腺素能β2受体激动剂, 大鼠

Abstract: ObjectiveTo determine whether the β2-agonist, clenbuterol, can improve recovery of locomotor function following spinal cord injury.MethodsThe spinal cords of rats were contused with a weight-drop apparatus similar to the NYU impactor at the lever of T10. Locomotor function was determined with the Basso, Beattie, Bresnahan (BBB) Scale. Following 6 weeks of behavioral evaluation, the spinal cords were received histological examination.ResultsClenbuterol improved the recovery of locomotor function and increased the amount of spared spinal cord tissue.ConclusionClenbuterol caused the enhancement of recovery of locomotor function and spared spinal cord tissue following contusion.

Key words: clenbuterol, spinal cord injury, locomotor function