《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (07): 507-508.

• 专题 • 上一篇    下一篇

益脑通络胶囊对缺血再灌注大鼠弥散加权像及能量代谢的影响

张梅奎1; 刘买利2; 尹岭1; 王雪松2; 张许2; 吴义根3; 姚斌1; 金香兰1   

  1. 1.解放军总医院神经信息中心 北京市 100853;2.中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室 湖北武汉市 430071;3.中国科学院高能物理研究所 北京市 100039
  • 收稿日期:2005-01-13 出版日期:2005-07-25 发布日期:2005-07-25

Effect of Yinaotongluo Capsule on diffuse weighting image and energy metabolism of ischemia-reperfused rats

ZHANG Mei-kui, LIU Mai-li, YIN Ling, et al   

  1. Informational Centre of Neurology, General Hospital of the PLA, Beijing 100853,China
  • Received:2005-01-13 Published:2005-07-25 Online:2005-07-25

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被引次数

3

摘要： 目的研究益脑通络胶囊对缺血再灌注大鼠弥散加权像及能量代谢的影响。方法运用脑缺血再灌注损伤大鼠模型及磁共振弥散加权成像和波谱技术(MRS)。结果与模型组相比,益脑通络胶囊治疗组3h和5d的磁共振弥散加权像梗死灶的面积明显减小,而且强度也明显降低。1H MRS谱的乳酸峰值比模型组明显降低,N乙酰天门冬氨酸比模型组增大。结论益脑通络胶囊能够有效地改善缺血再灌注后能量代谢,改善脑缺血,减少神经元的功能受损及死亡。

关键词: 益脑通络胶囊, 脑缺血, 缺血再灌注, 弥散加权像, 氢谱, 大鼠

Abstract: ObjectiveTo explore the effect of Yinaotongluo Capsule on diffuse weighting image and enenery metabolism of ischemia-reperfuing rat.MethodsMagnetic resonance diffusion-weighted imaging(DWI) and 1H and magnetic resonance spectroscopy(MRS) were performed in different brain regions in focal cerebral ischemic-reperfusion injury model rats. ResultsYinaotongluo Capsule could significantly reduce the area and the intensity of infarction of rats by DWI 3 h and 5 d after treatment compared with the model group.The result of 1H MRS examination demonstrated Lac peak was lower and NAA peak higher than that of the model group. ConclusionYinaotongluo Capsule can effectually improve enenery metabolism during cerebral ischemia and reperfuing, so that to reduce the neuronal dysfunction and death in infarcts at the late stage.

Key words: Yinaotongluo Capsule, cerebral ischemia, ischemia and reperfusion, magnetic resonance diffusion-weighted imaging(DWI), 1H and magnetic resonance spectroscopy(MRS), rat