《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (06): 431-432.

• 专题 • 上一篇    下一篇

阿托伐他汀降脂治疗对血管内皮舒张功能的康复作用

秦玲1; 杨晓英2; 李洋1; 翟坤光3   

  1. 1.吉林大学第一医院心内科 吉林长春市 130021;2.吉林大学第一医院电诊科 吉林长春市 130021;3.吉林大学前卫医院内科 吉林长春市 130011
  • 收稿日期:2005-04-20 出版日期:2005-06-25 发布日期:2005-06-25

Effect of atorvastatin on hypercholesterolemia and endothelium-dependent vasodilatation

QIN Ling, YANG Xiao-ying, LI Yang, et al   

  1. The Department of Cardiology, The First Hospital, Jilin University, Changchun 130021, Jilin, China
  • Received:2005-04-20 Published:2005-06-25 Online:2005-06-25

PDF (PC)

被引次数

21

摘要： 目的探讨阿托伐他汀的降脂作用和对血管内皮依赖性舒张功能的影响。方法42例高胆固醇血症患者应用阿托伐他汀治疗8周,观察治疗前后血清胆固醇变化;40例健康者作对照组。采用高分辨超声技术在治疗前后进行血管内皮依赖性舒张功能检测。结果42例高胆固醇血症患者治疗前肱动脉血流介导性舒张为(3.66±0.72)%,较对照组的(13.18±1.23)%显著减弱(P<0.001);服用阿托伐他汀10～20mg/d8周后,肱动脉内皮舒张功能较治疗前显著改善,为(10.98±1.57)%(P<0.001),且血清胆固醇从(7.11±0.70)mmol/L降至(5.86±0.59)mmol/L(P<0.01)。结论高胆固醇血症患者存在血管内皮依赖性舒张功能障碍,阿托伐他汀不但有明显的降脂作用,而且对血管内皮舒张功能有明显的康复作用。

关键词: 阿托伐他汀, 高胆固醇血症, 血管内皮舒张功能

Abstract: ObjectiveTo investigate the effect of atorvastatin on hypercholesterolemia and endothelium-dependent vasodilatation.Methods42 hypercholesterolemic patients took atorvastatin for 8 weeks, and serum cholesterol was measured before and after the treatment. High-resolution ultrasound endothelium-dependent vasodilatation was measured in hypercholesterolemic group before and after the treatment, with 40 healthy subjects as the control group.ResultsThe flow-induced dilation of the brachial artery of hypercholesterolemic group was (3.66±0.72)% much reduced compared with that of the control subjects (13.18±1.23)% (P<0.001). After 8 weeks treated by atorvastatin 10～20 mg/d, flow-induced dilation of the brachial artery of hypercholesterolemic group increased to (10.98±1.57)% much improved (P<0.001), and serum cholesterole declined from (7.11±0.70) mmol/L to ( 5.86±0.59) mmol/L (P<0.01).ConclusionHypercholesterolemic patients have endothelium-dependent vasodilatation dysfunction, atorvastatin not only reduces cholesterole but also recovers endothelium vasodilatation function.

Key words: atorvastatin, hypercholesterolemia, endothelium vasodilatation function