《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (06): 425-426.

• 专题 • 上一篇    下一篇

贝那普利联合氢氯噻嗪对合并多重危险因素高血压的疗效

安晓香   

  1. 北京博仁医院心内科 北京市 100054
  • 收稿日期:2004-09-01 出版日期:2005-06-25 发布日期:2005-06-25

Effect of benazepril combined with hydrochlorothiazide on hypertension complicated with multiple risk factors

AN Xiao-xiang   

  1. Department of Cardiac Internal Medicine, The Beijing Boren Hospital, Beijing 100054, China
  • Received:2004-09-01 Published:2005-06-25 Online:2005-06-25

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被引次数

3

摘要： 目的观察贝那普利联合氢氯噻嗪对合并多重心血管危险因素高血压的疗效。方法87例原发性高血压患者分为A组(n=40,危险因素<3个)和B组(n=47,危险因素≥3个)。所有患者给予贝那普利10mg、氢氯噻嗪12.5mg,每日1次口服,共治疗24周。观察治疗前后静息坐位心率、血压和心脏超声参数的变化。结果治疗后两组患者的收缩压、舒张压及心脏超声参数等指标均明显下降(P<0.05～0.01),且A组心脏超声参数变化较B组明显(P<0.05)。结论贝那普利联合氢氯噻嗪能有效干预伴随多重心血管危险因素高血压患者的血压、脉压及左室肥厚。

关键词: 贝那普利, 氢氯噻嗪, 危险因素, 高血压, 疗效

Abstract: ObjectiveTo observe the effect of benazepril combined with hydrochlorothiazide on hypertension complicated with multiple risk factors.Methods87 hypertensive patients were divided into group A (n=40, risk factors <3) and group B (n=47, risk factors ≥3). All patients were treated with benazepril 10 mg and hydrochlorothiazide 12.5 mg, once per day. Follow-up was performed for 24 weeks. The heart rates, blood pressures, and cardiac ultrasound parameters of all patients were tested before and after treatment.ResultsAfter treatment, the systolic pressure, diastolic pressure and values of cardiac ultrasound parameters of all patients decreased significantly (P<0.05～0.01), and changes of parameters of the group A were greater than that in the group B (P<0.05).ConclusionBenazepril combined with hydrochlorothiazide may improve the blood pressure, pulse pressure and left ventricular hypertrophy in hypertensive patients with multiple risk factors.

Key words: benazepril, hydrochlorothiazide, risk factors, hypertension, therapeutic effect