《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (06): 415-416.

• 专题 • 上一篇    下一篇

低剂量雄激素对心肌梗死后心衰成年雄兔血清雄激素水平的影响

樊瑾; 李小鹰; 娄卫民; 沈正   

  1. 解放军总医院老年心内科 北京市 100853
  • 收稿日期:2005-03-07 出版日期:2005-06-25 发布日期:2005-06-25

Effects of low dose androgen treatment on serum androgen levels in male adult rabbits postinfarction CHF model

FAN Jin, LI Xiao-ying, LOU Wei-min, et al   

  1. The Department of Geratology, The General Hospital of PLA, Beijing 100853, China
  • Received:2005-03-07 Published:2005-06-25 Online:2005-06-25

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被引次数

5

摘要： 目的观察低剂量雄激素十一酸睾酮(TU)和脱氢表雄酮(DHEA)对心肌梗死后心衰雄兔血清雄激素水平的影响。方法对48只4～5月龄健康雄性新西兰大白兔随机行冠状动脉结扎(n=40)或假手术(n=8)。3周后将存活的30只模型兔随机分为3组分别给予TU3mg/kg/2周肌肉注射(TU组,n=10)、DHEA3mg/kg/d口服(DHEA组,n=10)或安慰剂(MI组,n=10)治疗3个月。分别于第0、3、15周观察血清雄激素水平。结果模型兔3周时左室射血分数为(47.6±4.5)%与假手术组的(66.7±5.8)%有显著性差异(P<0.05),应用小剂量TU/DHEA治疗12周后血清游离睾酮升至正常范围,硫酸脱氢表雄酮浓度高于假手术组(P<0.05)。结论本研究中采用的TU和DHEA补充剂量接近心肌梗死后雄兔需要的生理剂量。

关键词: 兔, 雄激素, 心力衰竭

Abstract: ObjectiveTo investigate the effects of low dose testosterone undecanonate (TU) and dehydroepiandrosterone (DHEA) on serum androgen levels in male adult rabbits postinfarction congestive heart failure (CHF) model.Methods48 male 4～5 months old New Zealand rabbits were randomly assigned to ligation of first branch of left coronary artery (n=40) or sham operation (n=8). 3 weeks later, 30 survived model rabbits were randomly treated with TU 3 mg/kg per 2 weeks intramuscular injection (TU group, n=10), DHEA 3 mg/kg/d oral (DHEA group, n=10) or placebo (placebo group, n=10) for 3 months. Serum androgen changes were recorded at 0th, 3rd and 15th week.ResultsAt 3rd week after peration, left ventricular ejection fraction of model animals was 47.6±4.5% lower than that of the sham group (66.7±5.8%) (P<0.05). Serum free testosterone level of model animals returned to normal ranges after low dose TU or DHEA treatment, otherwise DHEAS level was higher than the sham group (P<0.05).ConclusionThe doses used in this research reached physiological dosage to male adult rabbits in postinfarction CHF model.

Key words: rabbit, androgen, congestive heart failure (CHF)