《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (05): 377-378.

• 临床研究 • 上一篇    下一篇

经颅多普勒超声对降颅压药物的评价

刘凤君   

  1. 北京大学第一医院神经内科 北京市 100034
  • 收稿日期:2005-01-13 出版日期:2005-05-25 发布日期:2005-05-25

Transcranial Doppler evaluates the effect of drugs on reducing the intracranial pressure

LIU Feng-jun   

  1. Department of Neurology,Peking University First Hospital, Beijing 100034, China
  • Received:2005-01-13 Published:2005-05-25 Online:2005-05-25

PDF (PC)

被引次数

2

摘要： 目的考察经颅多普勒超声(TCD)评价降颅压药物疗效的可行性。方法应用TCD监测20例(甘露醇组10例,甘油组10例)高颅压患者的用药前后大脑中动脉(MCA)流速变化。结果甘露醇组在用药后30 min MCA流速增至高峰,与用药前比较有非常高度显著性差异(P<0.001),持续时间约4～6 h。甘油组在用药后2h MCA流速增至高峰,与用药前比较有非常高度显著性差异(P<0.001),6～8h流速逐渐降低,至10～12h恢复至用药前水平。结论TCD可用于监测颅内压的变化及评价降颅内压药物的疗效。

关键词: 经颅多普勒超声, 高颅压, 脑血流, 药物评价

Abstract: ObjectiveTo investigate the feasibility of transcranial Doppler (TCD) in evaluating the effect of drugs on reducing the intracranial pressure.Methods20 patients who were treated with 20% mannitol (10 cases) and 10% glycerin (10 cases) separately were monitored the changes of blood flow velocity of middle cerebral artery (MCA) with TCD before and after treatment. ResultsIn mannitol group, The peak time presented at 30 min (P<0.001) after drug application and continued 4～6 h after treatment. In glycerin group, the peak time presented at 2 h (P<0.001) after drug application and continued 6～8 h after treatment.ConclusionTCD can monitor the changes of of blood flow velocity of middle cerebral artery (MCA) and thereby evaluate the effects of drugs on reducing intracranial pressure.

Key words: transcranial Doppler, intracranial hypertension, cerebral blood flow, drug evaluation