《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (05): 370-371.

• 临床研究 • 上一篇    下一篇

同型半胱氨酸与脑梗死大小的相关性研究

李娜; 张玉果; 郭晓华; 董玉娟; 张进贵   

  1. 1.河北医科大学第三医院神经内科 石家庄市 050051;2.河北医科大学第三医院实验中心 石家庄市 050051
  • 收稿日期:2004-10-13 出版日期:2005-05-25 发布日期:2005-05-25

Association between homocysteine and cerebral infarction

LI Na,ZHANG Yu-guo,GUO Xiao-hua, et al   

  1. Department of Neurology,the Third Hospital Affilicated to Hebei Medical University,Shijiazhuang 050051, Hebei, China
  • Received:2004-10-13 Published:2005-05-25 Online:2005-05-25

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被引次数

4

摘要： 目的探讨血浆同型半胱氨酸水平与脑梗死及其不同亚型之间的关系。方法选取105 例脑梗死患者,参照TOAST标准分为大梗死(56例)和小梗死(49例)2个亚组。对照组为健康体检者50名。采用酶联免疫吸附法测定空腹血浆总同型半胱氨酸水平。结果脑梗死组血浆同型半胱氨酸水平为(24.85±24.56)μmol/L,高于对照组(16.18±6.97)μmol/L(P<0.05);大梗死组血浆同型半胱氨酸水平为(30.46±31.16)μmol/L,高于小梗死组(18.43±10.73)μmol/L和对照组(均P<0.05);小梗死组和对照组之间无显著性差异。结论大梗死组血浆同型半胱氨酸水平升高,提示同型半胱氨酸水平升高是动脉粥样硬化性脑梗死的独立危险因素。

关键词: 同型半胱氨酸, 脑梗死, 动脉粥样硬化

Abstract: ObjectiveTo investigate the association between homocysteine and cerebral infarction, as well as between different subtypes of cerebral infarction.Methods105 cases with cerebral infarction were divided into two subgroups, according to TOAST criteria, large-artery disease and small-artery disease.In addition,50 normal persons were selected as control group.Fasting blood samples were drawn from antecubital vein for measurement of plasma total homocysteine,glucose and lipids.Enzyme conversion immunoassay was applied to detect plasma total homocysteine (tHcy) levels.ResultsThe mean tHcy of cerebral infarction, which was (24.85±24.56) μmol/L, was significantly higher than that of control group, which was (16.18±6.97) μmol/L(P<0.05).There was a significant difference of homocysteine between large-artery disease,which was (30.46±31.16) μmol/L, and small-artery disease,which was (18.43±10.73) μmol/L,or the control group(P<0.05),but there was no significant difference between small-artery disease and the control group. ConclusionThe mean tHcy significantly elevated in large-artery disease,which indicated that elevated plasma homocysteine levels is an independent risk factor for atherosclerotic vascular disease.

Key words: homocysteine, cerebral infaction, atherosclerosis, vascular disease